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A previous study found a molecular mimicry mechanism may associate a
rotavirus protein with celiac disease. Now a new study of rotavirus
antibodies in 1,931 children carrying HLA alleles for celiac disease in
the Denver metropolitan area seems to show that the risk of developing
celiac disease increases as the frequency of rotavirus infection
increases. The study followed children from infancy, taking blood samples
at 9, 15, and 24 months and annually, thereafter. 54 children developed
celiac disease at a median age of 4.4 years. The study found "Frequent
rotavirus infections predicted a higher risk of celiac disease
autoimmunity (compared with zero infections, rate ratio 1.94, 95%
confidence interval [CI] 0.39-9.56, for one infection and rate ratio 3.76,
95% CI 0.76-18.7, for 2 or more infections, rate ratio for trend per
increase in number of infections = 1.94, 95% CI 1.04-3.61, p= 0.037)."
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Am J Gastroenterol. 2006 Oct;101(10):2333-40.
Rotavirus infection frequency and risk of celiac disease autoimmunity in
early childhood: a longitudinal study.Stene LC, Honeyman MC, Hoffenberg
EJ, Haas JE, Sokol RJ, Emery L, Taki I, Norris JM, Erlich HA, Eisenbarth
GS, Rewers M.
Barbara Davis Center for Childhood Diabetes, University of Colorado School
of Medicine, Aurora, Colorado.
< http://dx.doi.org/10.1111/j.1572-0241.2006.00741.x >
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Previous study:
PLoS Medicine Volume 3, Issue 9, SEPTEMBER 2006
In Celiac Disease, a Subset of Autoantibodies against Transglutaminase
Binds Toll-Like Receptor 4 and Induces Activation of Monocytes
Giovanna Zanoni, Riccardo Navone, Claudio Lunardi, Giuseppe Tridente,
Caterina Bason, Simona Sivori, Ruggero Beri, Marzia Dolcino, Enrico
Valletta, Roberto Corrocher, Antonio Puccetti
Editor's Summary (READ FIRST!)
< http://dx.doi.org/10.1371/journal.pmed.0030358#editor >
Full Text
< http://dx.doi.org/10.1371/journal.pmed.0030358 >
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