PALEOFOOD Archives

Paleolithic Eating Support List

PALEOFOOD@LISTSERV.ICORS.ORG

Options: Use Forum View

Use Monospaced Font
Show Text Part by Default
Show All Mail Headers

Message: [<< First] [< Prev] [Next >] [Last >>]
Topic: [<< First] [< Prev] [Next >] [Last >>]
Author: [<< First] [< Prev] [Next >] [Last >>]

Print Reply
Subject:
From:
Reply To:
Paleolithic Eating Support List <[log in to unmask]>
Date:
Mon, 18 Dec 2006 11:01:02 -0500
Content-Type:
text/plain
Parts/Attachments:
text/plain (49 lines)
> I forwarded the betacellulin info to a friend who eats pretty 
> naturally but she is obsessed with dairy.  She asked me if 
> betacellulin is found in goat's milk.  Does anyone know?
> 
> Paula H.
> 


Since betacellulin is found in the blood, colostrum and milk of bovines
("Measurement of betacellulin levels in bovine serum, colostrum and milk,"
Journal of Endocrinology,
http://joe.endocrinology-journals.org/cgi/content/abstract/168/1/203), as
well as in humans, and apparently helps fetuses and infants to develop, my
guess is that it is found in all mammals. 


Goats are mentioned specifically here: "Goat Anti-Human Betacellulin
Polyclonal Antibody, Biotin Conjugated from R&D Systems"
(http://www.biocompare.com/itemdetails.asp?itemid=356346), though I don't
know what the "anti-human antibody" is.


This report appears to indicate that epidermal growth factor receptors,
which are activated by betacellulin, are found in all mammals:

EGFR
http://www.sigmaaldrich.com/sigma/rbi-handbook/rbibook5_egfr.pdf

"Epidermal growth factor receptor (EGFR), its family members Her-2/ErbB-2,
Her-3, Her-4 and their ligands, are involved in over 70% of all cancers.
....

All four receptors are expressed in mammals. A single ortholog of the
receptor is expressed in
D. melanogaster and C. elegans...."


This report says that betacellulin may help infants' GI tracts develop
during the first few weeks of birth:

Identification of betacellulin as a major peptide growth factor in milk:
purification, characterization and molecular cloning of bovine betacellulin.
A J Dunbar, I K Priebe, D A Belford, and C Goddard
Biochem J. 1999 December 15; 344(Pt 3): 713-721. 

"The identification of BTC [betacellulin] in milk raises the possibility
that it has a major role in the growth and development of the neonatal
gastrointestinal tract."

ATOM RSS1 RSS2