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From:
ken barber <[log in to unmask]>
Reply To:
Cerebral Palsy List <[log in to unmask]>
Date:
Fri, 27 Oct 2006 10:18:58 -0700
Content-Type:
text/plain
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text/plain (222 lines)
that question did come to my mind. 

--- "Kendall D. Corbett" <[log in to unmask]>
wrote:

> Ken and Kat,
> 
> I also wonder what would have happened had the study
> used rat stem
> cells rather than human stem cell implanted in rats.
>  A woman I worked
> with had a kidney transplant several years back, and
> later developed a
> tumor in that kidney and ureter.  I'm not saying for
> sure it was some
> form of auto immune response, but I'd think the
> likelihood of an
> autoimmune elated cancer developing would be higher
> when cros-species
> transplantation is performed.  I'm not advocating
> doing experimental
> research on humans, but a check to see if tumors
> develop in rats with
> Parkinson's who are given rat stem cells would seem
> logical.
> 
> Kendall
> 
> On 10/27/06, Kathleen Salkin <[log in to unmask]>
> wrote:
> > The study was truly inconclusive as they killed
> the test animals
> > before any tumors formed.   So we don't know if
> the tumors would have
> > been benign or malignant, or even if they would
> have formed.  Also,
> > would this have been the result of short-term
> treatment or long-
> > term?  Too many questions to be really conclusive.
> >
> > Kat
> >
> >
> > On 27 Oct 2006, at 00:37, Kendall D. Corbett
> wrote:
> >
> > Ken,
> >
> > Is this the link you were talking about?  If so,
> it does indicate an
> > area where caution should be observed, but since
> there was improvement
> > of the Parkinson's symptoms, I'd say it's too
> early to abandon the
> > research entirely, especially since even in this
> study, the results
> > seem to be inconclusive.
> >
> > Kendall
> >
> > http://today.reuters.com/news/articlenews.aspx?
> >
>
type=healthNews&storyID=2006-10-23T215819Z_01_TON379089_RTRUKOC_0_US-
> > STEM-CELLS.xml&WTmodLoc=NewsArt-C2-NextArticle-1
> >
> > Stem cells might cause brain tumors, study finds
> >
> > WASHINGTON (Reuters) - Injecting human embryonic
> stem cells into the
> > brains of Parkinson's disease patients may cause
> tumors to form, U.S.
> > researchers reported on Sunday.
> >
> > Steven Goldman and colleagues at the University of
> Rochester Medical
> > Center in New York said human stem cells injected
> into rat brains
> > turned into cells that looked like early tumors.
> >
> > Writing in the journal Nature Medicine, the
> researchers said the
> > transplants clearly helped the rats, but some of
> the cells started
> > growing in a way that could eventually lead to a
> tumor.
> >
> > Various types of cell transplants are being tried
> to treat Parkinson's
> > disease, caused when dopamine-releasing cells die
> in the brain.
> >
> > This key neurotransmitter, or message-carrying
> chemical, is involved
> > in movement and Parkinson's patients suffer muscle
> dysfunction that
> > can often lead to paralysis. Drugs can slow the
> process for a while
> > but there is no cure.
> >
> > The idea behind brain cell transplants is to
> replace the dead cells.
> > Stem cells are considered particularly promising
> as they can be
> > directed to form the precise desired tissue and do
> not trigger an
> > immune response.
> >
> > Goldman's team used human embryonic stem cells.
> Taken from days-old
> > embryos, these cells can form any kind of cell in
> the body. This batch
> > had been cultured in substances aimed at making
> them become brain
> > cells.
> >
> > Previous groups have tried to coax stem cells into
> becoming
> > dopamine-releasing cells.
> >
> > Goldman's team apparently succeeded and
> transplanted them into the
> > rats with an equivalent of Parkinson's damage. The
> animals did get
> > better.
> >
> > But the grafted cells started to show areas that
> no longer consisted
> > of dopamine-releasing neurons, but of dividing
> cells that had the
> > potential to give rise to tumors.
> >
> > The researchers killed the animals before they
> could know for sure,
> > and said any experiments in humans would have to
> be done very
> > cautiously.
> >
> > Scientists have long feared that human embryonic
> stem cells could turn
> > into tumors, because of their pliability.
> >
> > Opponents of embryonic stem cell research cite
> such threats. Many
> > opponents, including President George W. Bush and
> some members of
> > Congress, believe it is immoral to destroy human
> embryos to obtain
> > their stem cells.
> >
> >
> > (c) Reuters 2006. All Rights Reserved.
> >
> >
> >
> >
> >
> > On 10/26/06, ken barber <[log in to unmask]>
> wrote:
> > > in case you haven't heard one of the latest
> studies of
> > > injecting stemcells into the brain show the
> propensity
> > > of causing cancer and tumors. i wish i still had
> the
> > > link.
> > > we'll have to agree to disagree on mr. fox.
> > >
> > > --- "Kendall D. Corbett"
> <[log in to unmask]>
> > > wrote:
> > >
> > > > Ken, since you've got your asbestos suit on, 
> I
> > > > don't see it as Fox
> > > > "playing the pity card," as you put it.  He's
> > > > letting the public see
> > > > the actual effects of the disease that he has.
>  Stem
> > > > cell research has
> > > > the potential to more effectively treat, if
> not cure
> > > > this condition.
> > > > Since your Mom (and my uncle ) died from
> > > > Parkinson's, and a good
> > > > friend is very seriously disabled by it, my
> thought
> > > > is that research
> > > > should be continued, especially since halting
> stem
> > > > cell research is
> > > > not going to halt abortion.  If a fetus is to
> be
> > > > aborted anyway, which
> > > > should always be the last option, what's so
> wrong
> > > > with using some of
> > > > the tissue that would otherwise be destroyed
> to
> > > > improve the lives of
> > > > others?
> > > > Kendall
> > > >
> > > > On 10/25/06, ken barber <[log in to unmask]>
> wrote:
> > > > > well, kat he has admitted to not taking his
> meds
> 
=== message truncated ===


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