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Thu, 24 May 2007 07:04:31 -0400 |
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<<Disclaimer: Verify this information before applying it to your situation.>>
Artielle ImmunoTherapeutics is an Oregon company developing a new class of
immunotherapy drugs called RTLs (Recombinant T Cell Receptor Ligands).
RTLs are proteins engineered to have some specific properties of MHC II
antigen presenting molecules. In celiac disease MHC II molecules bind to and
present gluten peptides to T cell receptors resulting in release of inflammatory
chemicals and subsequent tissue destruction. RTLs can be administered
therapeutically to compete with and overwhelm the celiac disease specific
MHC II molecules. The RTLs are designed to takeup gluten peptides and
present them to T cell receptors causing release of anti-inflammatory
chemicals instead of inflammatory chemicals, thereby preventing and
interrupting the destructive cascade of tissue damage associated with celiac
disease.
RTL1000 is an RTL drug currently in human trials designed to treat multiple
sclerosis. Artielle is already designing an RTL drug to specifically treat celiac
disease. Human trials for celiac disease would follow successful MS trials.
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Artielle ImmunoTherapeutics
< http://www.artielle.com >
< http://www.artielle.com/DrugDev_Celiac.php >
< http://www.artielle.com/Tech_Over.php >
(See the Animation)
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FIRST NW PATIENT TO RECEIVE OHSU/VAMC-INVENTED MS DRUG (May 21,
2007)
http://www.ohsu.edu/ohsuedu/newspub/052107ms.cfm
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Curr Drug Targets Inflamm Allergy. 2005 Apr;4(2):185-93.
Systemic immunomodulation of autoimmune disease using MHC-derived
recombinant TCR ligands.
Burrows GG.
Abstract:
< http://dx.doi.org/10.2174/1568010053586363 >
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J Biol Chem. 2001 Jun 29;276(26):24170-6.
Design, engineering, and production of human recombinant t cell receptor
ligands derived from human leukocyte antigen DR2.
Chang JW, Mechling DE, Bachinger HP, Burrows GG.
Free Full Text:
< http://www.jbc.org/cgi/content/full/276/26/24170 >
* * *
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Archives are at: Http://Listserv.icors.org/SCRIPTS/WA-ICORS.EXE?LIST=CELIAC
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