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Subject:
From:
Roy Jamron <[log in to unmask]>
Reply To:
Roy Jamron <[log in to unmask]>
Date:
Thu, 30 Mar 2006 23:30:58 -0500
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<<Disclaimer: Verify this information before applying it to your situation.>>

Goodness!  Another coincidence!  Here's another new, free article directly 
related to my recent List posting "Liver Damage and the Intestinal Mucosa":

---------
World J Gastroenterol  2006 March 14;12(10):1493-1502
Gut flora and bacterial translocation in chronic liver disease 
John Almeida, Sumedha Galhenage, Jennifer Yu, Jelica Kurtovic, Stephen M 
Riordan

Free full text:
http://www.wjgnet.com/1007-9327/12/1493.asp

Abstract

Increasing evidence suggests that derangement of gut flora is of 
substantial clinical relevance to patients with cirrhosis. Intestinal 
bacterial overgrowth and increased bacterial translocation of gut flora 
from the intestinal lumen, in particular, predispose to an increased 
potential for bacterial infection in this group. Recent studies suggest 
that, in addition to their role in the pathogenesis of overt infective 
episodes and the clinical consequences of sepsis, gut flora contributes to 
the pro-inflammatory state of cirrhosis even in the absence of overt 
infection. Furthermore, manipulation of gut flora to augment the 
intestinal content of lactic acid-type bacteria at the expense of other 
gut flora species with more pathogenic potential may favourably influence 
liver function in cirrhotic patients. Here we review current concepts of 
the various inter-relationships between gut flora, bacterial 
translocation, bacterial infection, pro-inflammatory cytokine production 
and liver function in this group.

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