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<<Disclaimer: Verify this information before applying it to your situation.>>
A new study identified a peptide which causes an immune reaction in a
majority of active CD patients but no such reaction in any CD patients on
a gluten-free diet. Antibodies to this celiac peptide also recognize and
bind to the rotavirus protein VP-7 and cause increased intestinal
permeability. Antibodies to VP-7 produced in rabbits also increase
intestinal permeability. The celiac peptide also binds to Toll-like
receptor 4 and activates monocytes (white blood cells active in innate
immunity.) IgA and IgG antibodies to rotavirus protein VP-7 are present
in a majority of CD patients and to a much lesser percent of the general
population. This suggests VP-7 may be involved in the pathogenesis of CD
through a molecular mimicry mechanism.
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PLoS Medicine Volume 3, Issue 9, SEPTEMBER 2006
In Celiac Disease, a Subset of Autoantibodies against Transglutaminase
Binds Toll-Like Receptor 4 and Induces Activation of Monocytes
Giovanna Zanoni, Riccardo Navone, Claudio Lunardi, Giuseppe Tridente,
Caterina Bason, Simona Sivori, Ruggero Beri, Marzia Dolcino, Enrico
Valletta, Roberto Corrocher, Antonio Puccetti
Editor's Summary (READ FIRST!)
< http://dx.doi.org/10.1371/journal.pmed.0030358#editor >
Full Text
< http://dx.doi.org/10.1371/journal.pmed.0030358 >
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Note: If you have any problem with links, read this post from the Celiac
List archives:
< http://listserv.icors.org/archives/celiac.html >
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* Please remember some posters may be WHEAT-FREE, but not GLUTEN-FREE *
Archives are at: Http://Listserv.icors.org/SCRIPTS/WA-ICORS.EXE?LIST=CELIAC
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