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Date: | Thu, 30 Mar 2006 23:02:53 -0500 |
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<<Disclaimer: Verify this information before applying it to your situation.>>
Coincidentally, after my recent comments on the List about "Liver Damage
and the Intestinal Mucosa", a new, free review on liver disorders and
celiac disease has appeared. One cannot ignore the secondary effects and
symptoms that liver damage may add to those symptoms caused by gluten's
effect on the intestinal mucosa. Those unexplained aches and pains and
other symptoms and disorders which have frequently appeared on this List
may be a result of liver dysfunction.
Some notes: Elevated liver enzymes are the result of liver enzymes
released by damaged liver cells. The article cites one study stating "A
gluten-free diet for 1 to 10 years resulted in complete normalization of
liver chemistry tests in 95% patients." Normal liver chemistry tests DO
NOT necessarily mean that the liver is functioning normally and that no
damage remains. See: Special Considerations in Interpreting Liver
Function Tests - http://www.aafp.org/afp/990415ap/2223.html
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World J Gastroenterol 2006 March 14;12(10):1503-1508
Hepatobiliary and pancreatic disorders in celiac disease
Hugh James Freeman
Free full text:
http://www.wjgnet.com/1007-9327/12/1503.asp
Abstract
A variety of hepatic and biliary tract disorders may complicate the
clinical course of celiac disease. Some of these have been hypothesized to
share common genetic factors or have a common immunopathogenesis, such as
primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune
forms of hepatitis or cholangitis. Other hepatic changes in celiac disease
may be associated with malnutrition resulting from impaired nutrient
absorption, including hepatic steatosis. In addition, celiac disease may
be associated with rare hepatic complications, such as hepatic T-cell
lymphoma. Finally, pancreatic exocrine function may be impaired in celiac
disease and represent a cause of treatment failure.
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