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Date: | Sat, 29 Apr 1995 12:48:58 -0400 |
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<<Disclaimer: Verify this information before applying it to your situation.>>
Recently I asked Albert Fornace of our mailing list to try to find a
particular study using Medline. While he did not find the study I was
looking for, he forwarded the following which I thought would interest the
rest of the list.
UI - 92175590
AU - Arnason JA ; Gudjonsson H ; Freysdottir J ; Jonsdottir I ;
Valdimarsson H
TI - Do adults with high gliadin antibody concentrations have
subclinical gluten intolerance?
LA - Eng
MH - Adult ; Antibodies/*ANALYSIS ; Celiac Disease/*IMMUNOLOGY ;
Comparative Study ; Enzyme-Linked Immunosorbent Assay ; Female ;
Gliadin/*IMMUNOLOGY ; Human ; IgA/*ANALYSIS ; IgG/*ANALYSIS ;
Male ; Middle Age
RN - 0 (Antibodies) ; 0 (IgA) ; 0 (IgG) ; 9007-90-3 (Gliadin)
PT - JOURNAL ARTICLE
AB - Gliadin antibodies of the IgG and IgA isotypes and IgG subclasses
were measured in 200 adults who were randomly selected from the
Icelandic National Register. Those with the highest gliadin
antibody concentrations were invited with negative controls to
participate in a clinical evaluation. Neither the study subjects
nor the physicians who recorded and evaluated the clinical
findings were aware of the antibody levels. Significantly higher
proportion of the gliadin antibody positive individuals reported
unexplained attacks of diarrhoea (p = 0.03), and IgA gliadin
antibodies were associated with increased prevalence of chronic
fatigue (p = 0.0037). The gliadin antibody positive group also
showed significantly decreased transferrin saturation, mean
corpuscular volume and mean corpuscular haemoglobin compared with
the gliadin antibody negative controls. Serum folic acid
concentrations were significantly lower in the IgA gliadin
antibody positive individuals. On blind global assessment 15 of
the 48 participants were thought to have clinical and laboratory
features that are compatible with gluten sensitive enteropathy,
and 14 of these were in the gliadin antibody positive group (p =
0.013). Complaints that have not been associated with gluten
intolerance had similar prevalence in both groups with the
exception of persistent or recurrent headaches that were more
common in the gliadin antibody positive group. These findings
raise the possibility that a subclinical form of gluten
intolerance may be relatively common.
AD - Department of Immunology, National University Hospital,
Reykjavik, Iceland.
SO - Gut 1992 Feb;33(2):194-7
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