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Past studies on the effects of CD on pregnancies have been inconclusive.
Here is a new larger study which may have greater validity.
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Gastroenterology, Volume 129, Issue 2, Pages 454-463 (August 2005)
Celiac Disease and Risk of Adverse Fetal Outcome: A Population-Based Cohort
Study
Jonas F. Ludvigsson, Scott M. Montgomery, Anders Ekbom
Pediatric Department, Örebro University Hospital, Örebro, Sweden; Clinical
Epidemiology Unit, Department of Medicine, Karolinska University Hospital,
Karolinska Institute, Stockholm, Sweden; Clinical Research Center, Örebro
University Hospital, Linkoping, Sweden; Harvard Medical School, Boston,
Massachusetts
Background & Aims: Studies of maternal celiac disease (CD) and fetal
outcome are inconsistent, and low statistical power is likely to have
contributed to this inconsistency. We investigated the risk of adverse
outcomes in women with CD diagnosed prior to pregnancy and in women who did
not receive a diagnosis of CD until after the delivery. Methods: A national
register-based cohort study restricted to women aged 15-44 years with
singleton live born infants was used. We identified 2078 offspring to women
who had received a diagnosis of CD (1964-2001): 1149 offspring to women
diagnosed prior to birth and 929 offspring to women diagnosed after infant
birth. Main outcome measures were: intrauterine growth retardation, low
birth weight (<2500 g), very low birth weight (<1500 g), preterm birth (<37
gestational weeks), very preterm birth (<30 gestational weeks), and
caesarean section. Results: Undiagnosed CD was associated with an increased
risk of intrauterine growth retardation (OR = 1.62; 95% CI: 1.22-2.15), low
birth weight (OR = 2.13; 95% CI: 1.66-2.75), very low birth weight (OR =
2.45; 95% CI: 1.35-4.43), preterm birth (OR = 1.71; 95% CI: 1.35-2.17), and
caesarean section (OR = 1.82; 95% CI: 1.27-2.60). In contrast, a diagnosis
of CD made before the birth was not associated with these adverse fetal
outcomes. Conclusions: Undiagnosed maternal CD is a risk factor for
unfavorable fetal outcomes, but the risks are reduced when CD has been
diagnosed. CD diagnosed prior to pregnancy does not constitute a great a
risk as undiagnosed CD.
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