Existing drugs are reasonably good at treating 
the hallucinations and delusions of 
schizophrenia. But they are far less effective at 
treating the so-called negative symptoms of the 
disease ­ the lack of motivation and emotion that 
leave many patients unable to work or have normal 
social relationships. The side effects of 
existing medicines, which affect nearly all 
patients, are also severe. Older drugs like 
Thorazine often cause tics and movement 
disorders, while newer medicines typically have 
fewer effects on movement but can cause weight 
gain and other metabolic changes.

In the clinical trial whose results were reported 
yesterday, LY2140023 had none of those side 
effects and appeared to work about as well as 
Zyprexa at reducing symptoms. In the trial, which 
was conducted in Russia from August 2005 to June 
2006, patients were given the experimental drug, 
Zyprexa or a placebo. About 100 patients received the experimental medicine.

http://www.nytimes.com/2007/09/03/business/03drug.html?_r=1&ref=us&oref=slogin

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