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Subject:
From:
Charlotte Ward-Perkins <[log in to unmask]>
Reply To:
Charlotte Ward-Perkins <[log in to unmask]>
Date:
Wed, 16 Mar 2005 17:25:28 -0000
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<<Disclaimer: Verify this information before applying it to your situation.>>

This study has relevance for coeliacs with Sjogrens ("a gluten-free diet treatment may alleviate autoimmune inflammation" ) but also coeliacs without sjogren's as the study suggests more of us may be prone to it than previously thought ("the overlap between CD and SS maybe more extensive than is apparent at the first sight").
Full text available at:
http://www.blackwell-synergy.com/links/doi/10.1111/j.1601-0825.2004.01048.x/full/ 
Oral Diseases Volume 10 Issue 6 Page 330  - November 2004 doi:10.1111/j.1601-0825.2004.01048.x  

Oral findings in coeliac disease and Sjögren's syndrome 

P Patinen 1, L Aine 2 , P Collin 3 , J Hietanen 4,5 , M Korpela 3 , G Enckell 2 , H Kautiainen 6 , YT Konttinen 7,8 , T Reunala 9 

Objective: Both coeliac disease (CD) and Sjögren's syndrome (SS) have an autoimmune background and increased risk of oral mucosal and dental abnormalities. Individuals suffering concomitantly from CD and SS could even be at a higher risk.

 Study design: Oral mucosal and dental abnormalities were examined in 20 patients with CD + SS (mean age 61 years) and compared with age- and sex-matched controls with either CD or SS.

 Results: Oral mucosal changes were most common in SS (80%), followed by CD + SS (65%) and CD (40%). Coeliac-type dental enamel defects were found in 89% in CD + SS and in 88% in CD compared with only 25% in SS (P < 0.001). The median number of teeth was six in the CD + SS, 24 in the CD and 22 in the SS group. The DMF index was higher (P < 0.005) in the CD + SS than in the CD group. CD + SS was characterized by higher salivary flow rate (P < 0.001) and lower inflammatory focus score in the salivary glands (P < 0.01) than SS.

 Conclusions: The co-occurrence of CD and SS should be recognized because of its effects on dental and oral mucosal health. A lower salivary gland inflammatory focus score and higher salivary flow rate in CD + SS than in SS suggests that a gluten-free diet treatment may alleviate autoimmune inflammation.

NB

"Interestingly, the median focus score of the CD patient group was 2.1 and the interquartile range values being 1.03.1. This implies that several of the present patients with CD but without SS as diagnosed according to currently valid criteria could have a subclinical autoimmune focal sialoadenitis. Therefore, it is likely that the autoimmune exocrinopathy disease process characteristic for SS can start before the outbreak of the clinical disease. This also implies that the overlap between CD and SS maybe more extensive than is apparent at the first sight. It is also a matter of discussion whether SS in the patients with CD should be classified as secondary or primary SS."

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