Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE)

Three times out of four, patients could not get satisfaction from the first
drug they were prescribed in the study. They tended to switch either
because of side effects, such as severe weight gain or neurological
tremors, or because the drugs didn't ease the delusions, hallucinations and
emotional numbness that can cripple schizophrenia patients.

CATIE hands a major victory to Zyprexa (which results) also show that
Zyprexa causes more weight gain, high blood sugar and raised cholesterol
than its competitors.

One surprise for many was that the drug spekked perphenazine (sp), an
antipsychotic that was discovered in the 1950s and is now a dirt-cheap
generic, did as well as the other drugs.

"In the absence of clear-cut, clinically significant differences in
efficacy and effectiveness," Newcomer says, "the risk of medically
significant adverse events should have a major impact on prescribing
decisions."

http://www.forbes.com/home/health/2005/09/19/schizophrenia-drug-trial-cx_mh_0919schizophrenia.html

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