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Date: | Thu, 28 Sep 1995 10:15:54 EDT |
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<<Disclaimer: Verify this information before applying it to your situation.>>
The following is a guest post from Dr. Reichelt:
From: K.L.Reichelt @ rh.uio.no (Kalle Reichelt) @ MHS
Date: 09/28/95 08:23:24 AM
Hi.
It has been clearly established that bioactive and significant amounts of
protein and peptides are taken up from the gut.(1,2)
It is therefore not suprising that the same proteins can be measured in
mothers milk.(3-6). This has been done by immunological technique and also
demonstration that the proteins are not fragments of the precursors by
electrophoresis on acrylamide gels.Gliadin proteins see ref 6.
That this mechanism may have serious consequences is illustrated by the
many papers relating peptide fragments of milk proteins and the induction
of antibodies that destroy the beta-cells (insulin producing cells) and
cause diabetes mellitus.(7-9).Certain epilepsy is also related to gluten
(10).
References:
1: Gardner MLG (1994)Absorption of intact proteins and peptides. in Physiol
of gastrointestinal Tract 3 rd edit ( edit: LR Johnson) Raven
press,NYpp1795-1820.
2:Gardner MLG and Stffens K-J (eds)(1995) Absorption of orally adminsitered
enzymes. Springer Verlag,Berlin,Heidelberg.
3: AxelssonI et al (1986) Bovine bveta-lactoglobulin in human milk. Acta
Paed Scand 75: 702-707.
4:Kilshaw PJ and Cant AJ (1984) The passage of maternal dietary protein
into human breast milk .Int Arch Allergy and Appl Immunol 75: 8-15.
5; Stuart Ca et al (1984) Passage of cow s milk protein in breast milk
.Clin Allergy 14: 533-535.
6:Troncone R et al (1987) Passge of gliadin intio human breast milk. Acta
paediat Scand. 76: 453-456.
7:Karjalainen J et al (1992) Bovine albumin peptide as possible trigger of
insulin-dependent diabetes mellitus. New Eng J Med 327: 302-307.
8:Martin JM et al (1991) Milk protein in the etiology og insulin-dependent
diabetes mellitus (IDDM)Ann Med 23: 447-452.
9: Virtanen SM et al (1994) Diet,cow s milk protein antibodies and the risk
of IDDM in Finnish children. Diabteologica 37: 381-387.
!0:Gobbi G et al (1992) Coeliac disease ,epilepsy and cerebral calcifications.
The Lancet 340: 439-443-
All the best Cheers
TINY
K. Reichelt
Pediatric Research Institute
N-0027 Oslo, Norway
Tel: +47 22 86 90 45
Fax: +47 22 86 91 17
E-mail: [log in to unmask]
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