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Thought you might find it of interest
don in carlsbad, calif



Bellanti JA, Sabra A, Zeligs BJ.

Department of Pediatrics, the International Center for
Interdisciplinary Studies of Immunology, Georgetown University
Medical Center, Washington, DC 20007, USA. [log in to unmask]

OBJECTIVE: To review the current data that support the pivotal
function of the gastrointestinal immune system in health and disease
and its critical role in the pathogenesis of a wide variety of
clinical disorders associated with food allergy (FA).

DATA SOURCES: Internet-based literature search and our own data.

STUDY SELECTION: The studies included in this review were selected
based on the expert opinion of the authors.

RESULTS: In contrast to the beneficial expressions of
gastrointestinal-associated lymphoid tissue, which are seen with
relevance to newer methods of delivery of vaccines directly applied
to the gastrointestinal mucosal surfaces (eg, oral poliovirus,
rotavirus, Salmonella typhi vaccines), the adverse consequences of a
mucosal immune response gone astray are evidenced in many diseases
such as FA.

A classification of clinical disorders associated with FA based on
classic mechanisms of immunologic injury is presented, which includes
the following: (1) IgE-mediated, (2) non-IgE-mediated, and (3) mixed
IgE- and non-IgE-mediated disorders. Our study of immunologic
disturbance in patients with non-IgE FA revealed a pattern of
increased CD4+ and decreased TH1 cell counts in peripheral blood
mononuclear cells in contrast to patients with celiac disease, where
a pattern of increased CD8+ and TH1 cell counts in peripheral blood
mononuclear cells and increased CD8+ cell counts was seen.

CONCLUSIONS: The gastrointestinal immune response thus plays a
pivotal role in maintaining protective immunity in health and a
critical role in the pathogenesis of a wide variety of clinical
disorders associated with FA.

    PMID: 15562871 [PubMed - in process]

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