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The new issue of Gastroenterolgy is out with an interesting free article on
food allergy and a study on pregnancy in in women with CD.

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Gastroenterology, April 2005, Volume 128, Number 4, Pages 1089-1113

Gastrointestinal food allergy: New insights into pathophysiology and
clinical perspectives
Stephan Bischoff, Sheila E. Crowe

Free full text available in current issue at:
(Click on "Current Issue" for contents and go to Page 1089 to click
on "Full Text".)
http://www.gastrojournal.org/

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Gastroenterology, April 2005, Volume 128, Number 4, Pages 849-855

Fertility and pregnancy-related events in women with celiac disease: A
population-based cohort study

L.J. Tata, T.R. Card, R.F.A. Logan, R.B. Hubbard, C.J.P. Smith, J. West

Epidemiology and Public Health, University of Nottingham, Nottingham,
United Kingdom
Respiratory Medicine, Nottingham City Hospital, Nottingham, United Kingdom
Supported by The Wellcome Trust (grant 063800).
Address requests for reprints to: L. J. Tata, MSc, Division of Epidemiology
& Public Health, University of Nottingham, Clinical Sciences Building, City
Hospital, Hucknall Road, NG5 1PB, United Kingdom; fax: (44) 115-840-4771.
Email address: [log in to unmask] (L.J. Tata)

Abstract

Background & Aims: Previous studies have raised concern about reduced
fertility and increased adverse pregnancy-related events in women with
celiac disease, but none has estimated overall fertility compared with the
general female population. Methods: We compared computerized primary care
data for 1521 women with celiac disease with data for 7732 age- and
practice-matched women without celiac disease. We estimated population-
based rates of fertility and adverse pregnancy outcomes. Results: Crude
fertility rates were 48.2 and 47.7 live births per 1000 person-years for
women with and without celiac disease, respectively (rate ratio, 1.01; 95%
confidence interval, 0.90-1.14). Age-specific fertility rates showed that
women with celiac disease had lower fertility when younger but higher
fertility when older compared with women without celiac disease. This
increase in relative fertility with increasing age held whether women had
treated or untreated celiac disease. Risks of cesarean section (odds ratio,
1.33; 95% confidence interval, 1.03-1.70) and miscarriage (rate ratio,
1.31; 95% confidence interval, 1.06-1.61) were moderately higher in women
with celiac disease, but risks of assisted birth, breech birth,
preeclampsia, postpartum hemorrhage, ectopic pregnancy, stillbirth, and
termination were similar. Conclusions: Overall, women with celiac disease
have fertility similar to that of the general female population, but they
have their babies at an older age. Although our findings may reflect a
disease effect, the age shift in fertility rates and the increase in
cesarean section risk is consistent with socioeconomic or educational
advantages of women with celiac disease.

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