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Microflora and Hesperidin Teamup to Reduce Allergies/Bleeding

Intestinal microflora and the bioflavonoid, hesperidin, may work together
to reduce allergies.  Hesperidin is available from many fruits and
vegetables.  Malabsorption of hesperidin due to celiac disease or low
stomach acid plus the alteration of intestinal microflora may be
responsible for a decrease in histamine inhibition and increased allergic
reactions, also leading to increased bruising and bleeding conditions such
as nose-bleeding and hemmoroids.

In particular, I can relate to this.  I have been dealing with food
sensitivities, rectal bleeding, and I bruise very easily.  Perhaps I need
to supplement with hesperidin in addition to consuming Nancy's Yogurt.

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Info about Hesperidin and Bioflavonoids
http://www.acu-cell.com/bio.html

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Pharmacology. 2004 Aug;71(4):174-80

Antiallergic activity of hesperidin is activated by intestinal microflora.

Lee NK, Choi SH, Park SH, Park EK, Kim DH.

School of Oriental Medicine, Kyung Hee University, Seoul, Korea.

When hesperidin isolated from pericarpium of Citrus unshiu (family
Rutaceae) was incubated with human intestinal microflora, its main
metabolite was hesperetin, which was a main metabolite in urine of orally
hesperidin-administered rats. The antiallergic activity of hesperidin and
its metabolite hesperetin were investigated. Hesperidin did not inhibit the
histamine release from RBL-2H3 cells induced by IgE. However, its
metabolite hesperetin potently inhibited the histamine release from RBL-2H3
cells induced by IgE and the PCA reaction. The inhibitory activity of
hesperetin was found to be comparable with azelastine, a commercially
available antiallergic drug, and to potently inhibit prostaglandin E(2)
production in lipopolysaccharide-stimulated RAW 264.7 cells. Hesperetin
weakly inhibits cyclooxygenase 2 enzyme activities. These results suggest
that hesperidin may be a prodrug, which is metabolized to hesperetin by
intestinal bacteria. Copyright 2004 S. Karger AG, Basel

PMID: 15240993 [PubMed - in process]

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