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The featured story in current health news has been about the link between a
high-carb diet and breast cancer. Recently I posted on the List the recent
study "Malignancy and mortality in people with coeliac disease: population
based cohort study" which found that breast cancer risk was significantly
lower in celiacs on a GF-diet. Off-hand, I would say there is a very high
probability of a connection between these two results. A GF-diet is likely
to include less refined carbohydrates in addition to the elimination of
gluten.
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Study: Shunning carbs may cut breast-cancer risk
http://www.azstarnet.com/sn/health/33088.php
CBS News story with video (Paste address together)
http://www.cbsnews.com/stories/2004/08/06/earlyshow/contributors/emilysenay/
main634382.shtml
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Cancer Epidemiology Biomarkers & Prevention Vol. 13, 1283-1289, August 2004
Carbohydrates and the Risk of Breast Cancer among Mexican Women
Isabelle Romieu, Eduardo Lazcano-Ponce, Luisa Maria Sanchez-Zamorano,
Walter Willett and Mauricio Hernandez-Avila
Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico and
Departments of Nutrition and Epidemiology, Harvard School of Public Health
and Channing Laboratory, Department of Medicine, Brigham and Women's
Hospital and Harvard Medical School, Boston, Massachusetts
Full-text HTML (free):
http://cebp.aacrjournals.org/cgi/content/full/13/8/1283
Full-text PDF (free):
http://cebp.aacrjournals.org/cgi/reprint/13/8/1283
Abstract
Objective: High carbohydrate intake has been hypothesized to be a risk
factor for breast cancer, possibly mediated by elevated levels of free
insulin, estrogens, and insulin-like growth factor-1. Therefore, we
conducted a population-based case-control study among a Mexican population
characterized by relatively low fat and high carbohydrate intakes. Methods:
Women ages 20 to 75 years, identified through six hospitals in Mexico City
(n = 475), were interviewed to obtain data relating to diet (using a food
frequency questionnaire) and breast cancer risk factors. Controls (n =
1,391) were selected from the Mexico City population using a national
sampling frame. Results: Carbohydrate intake was positively associated with
breast cancer risk. Compared with women in the lowest quartile of total
carbohydrate intake, the relative risk of breast cancer for women in the
highest quartile was 2.22 [95% confidence interval (95% CI) 1.63-3.04],
adjusting for total energy and potential confounding variables (P for trend
< 0.0001). This association was present in premenopausal and postmenopausal
women (for highest versus lowest quartile, odds ratio 2.31, 95% CI 1.36-
3.91 in premenopausal women and odds ratio 2.22, 95% CI 1.49-3.30 in
postmenopausal women). Among carbohydrate components, the strongest
associations were observed for sucrose and fructose. No association was
observed with total fat intake. Discussion: In this population, a high
percentage of calories from carbohydrate, but not from fat, was associated
with increased breast cancer risk. This relation deserves to be
investigated further, particularly in populations highly susceptible to
insulin resistance.
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BMJ. 2004 Jul 21 [Epub ahead of print]
Full-text PDF (free):
http://bmj.bmjjournals.com/cgi/reprint/bmj.38169.486701.7Cv1
Malignancy and mortality in people with coeliac disease: population based
cohort study.
West J, Logan RF, Smith CJ, Hubbard RB, Card TR.
Division of Epidemiology and Public Health, University of Nottingham,
Queen's Medical Centre, Nottingham NG7 2UH.
OBJECTIVE: To quantify the risks of malignancy and mortality in people with
coeliac disease compared with the general population. DESIGN: Population
based cohort study. SETTING: General practice research database.
PARTICIPANTS: 4732 people with coeliac disease and 23 620 matched controls.
MAIN OUTCOME MEASURES: Hazard ratios for malignancy and mortality. RESULTS:
Of the 4732 people with coeliac disease, 134 (2.8%) had at least one
malignancy and 237 (5.0%) died. The overall hazard ratios were: for any
malignancy 1.29 (95% confidence interval 1.06 to 1.55), for mortality 1.31
(1.13 to 1.51), for gastrointestinal cancer 1.85 (1.22 to 2.81), for breast
cancer 0.35 (0.17 to 0.72), for lung cancer 0.34 (0.13 to 0.95), and for
lymphoproliferative disease 4.80 (2.71 to 8.50). The increased risk was
primarily in the first year after diagnosis, with the risk for only
lymphoproliferative disease remaining significantly raised thereafter.
After excluding events in the year after diagnosis, the hazard ratio for
malignancy was 1.10 (0.87 to 1.39) and for mortality was 1.17 (0.98 to
1.38), giving absolute excess rates of 6 and 17 per 10 000 person years,
respectively. CONCLUSIONS: People with coeliac disease have modest
increases in overall risks of malignancy and mortality. Most of this excess
risk occurs in the year of follow up after diagnosis. People with coeliac
disease also have a noticeably reduced risk of breast cancer. The mechanism
of this merits further attention as it may provide insights into the cause
of this common malignancy.
PMID: 15269095 [PubMed - as supplied by publisher]
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