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Date:
Sun, 2 Jun 1996 12:49:36 -0500
Subject:
Speculation on CD: Possible iniating factor
From:
Jim Barron <[log in to unmask]>
Parts/Attachments:
text/plain (26 lines)
<<Disclaimer: Verify this information before applying it to your situation.>>
 
Warning:   This is highly speculative for the purpose of intellectual
discussions.
 
There are various "carrier" chemicals around that can readily transport
molecules across the skin barrier and across lipid bilayers that are not
normally absorbed through this route.   (Dimethylsufloxide  (DMSO) is a
good example of this).  Could such carrier chemicals be used in the food
processing industry (perhaps an "ideal" (from THEIR point of view) way to
mix ingredients that do not readily mix)?
 Could such carrier chemicals, IF used, play an important role in
initiating CD (in some cases) by transporting undigested or partially
digested gluten/peptide fragments across the intestinal mucosa into the
bloodstream where they then initiate the antibody reaction (which might
then damage the mucosa in susceptible individuals (i.e.: with the right MHC
type) allowing the peptides to be routinely transported even without the
presence of the carrier chemical.      Could this explain why some
individuals with the genentic type for CD do not express the trait?
(i.e.: they are not exposed to an "ititiating" event which causes the
peptides to be transported into the bloodstream to generate the antibodies,
therefore their guts never become permeable, therefore they don't get CD.)
 
Jim Barron
Chapel Hill, NC

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