Because the flash drive is powered by the USB on the motherboard, and the voltage spike traveled through the mobo to fry the other drives, it is highly likely that the spike will also fry the flash drive.  Haven't had that happen, but it seems like a logical result.

>If a computer gets zapped with an over voltage spike bad enough to fry
>the main drives ("C", "D" etc.) would it fry the flash drive connected
>to a USB outlet?
>


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