----- Original Message -----
From: "Felix ossia" <[log in to unmask]>
To: "unima" <[log in to unmask]>
Sent: Friday, May 23, 2003 9:50 AM
Subject: [unima] Nigerian Records Breakthrough in Diabetes Cure - ThisDay
News 5-23-2003
> Nigerian Records Breakthrough in Diabetes Cure
> From Paul Ibe and Chuks Akunna in Abuja
>
> Persons suffering from diabetes may soon have cause to
> smile following the recent break-through recorded by a
> Nigerian scientist, Mr. Louis Obyo Obyo Nelson, in the
> cure for the deadly ailment, which affects more than
> 400 million people worldwide. In recognition of this
> feat, the United States government has granted Nelson
> US patent number 6,531,461 for his medication which
> can effectively treat type one and type two diabetes.
> A documented proof of the discovery shows that Nelson,
> who resides at Plot 574 Yakubu Gowon Crescent,
> Asokoro, Abuja filed his application for a United
> States patent June 4, 2001.
>
> The 'Medicament for the treatment of Diabetes' patent
> with application No. 09/873,560 was approved March 11
> this year. Unlike insulin which has been used for
> many decades to manage diabetes, Nelson's "wonder"
> drug can be administered orally, making it possible
> for patients to administer it as capsule, tablet or
> syrup. Insulin can only be injected into the body.
> Another feature of the new drug is that instead of
> merely "managing" the situation like insulin does, it
> offers "remission" of the condition to the point that
> it is possible to have a diabetic completely treated.
>
>
> The award to Nelson, a graduate of Chemistry from the
> University of Ibadan, was made on the strength of his
> research, which determined the exact chemical
> structure of the active ingredient. The research was
> also able to determine the quantity of the drug, which
> could be tolerated in the human body, and yet be able
> to stem the patient's condition. Diabetes is a
> potentially life threatening condition in mammals
> brought about by an inability of the mammals to
> produce insulin. Insulin, a polypeptide hormone
> produced in the pancreas of the mammal controls the
> amounts of glucose present in the blood by stimulating
> the uptake of glucose by the muscle and adipose
> tissue.
>
> The document stated that the compounds of the present
> invention, as isolated from the leaf of the common
> Vernonia amygdalina plant are particularly useful for
> the treatment of hyperglycemia. According to the
> document, the compounds of the present invention may
> bring about cell regeneration as trials involving
> hyperglycemic mammals have resulted in the restoration
> of complete insulin activity within six months. The
> extraction procedure, according to the documented
> patent, showed that the leaves of the plant Vernonia
> amygdalina were dried and ground to fine particles.
> The particles were then soaked in water; ethanol for
> one hour, after, which time the mixture was
> transferred to an extractor. The resulting mixture,
> according to the patent document, was filtered through
> a Whatman No 1 filter paper and concentrated in vacuo
> to provide the crude extract. The crude extract was
> then purified and fractionated by chromatography. The
> initial extract was orally administered to 26 patients
> all of whom had been previously diagnosed as suffering
> from insulin deficiency. For control, a group of five
> were used, who maintained diet discipline throughout
> the trial. The initial extract was dosed to the
> patient three times daily in 100mg aliquots for six
> months.
>
> The blood glucose levels of all 31 subjects were
> closely monitored. The document reveal that the 26
> patients receiving the initial extract no longer
> required maintaining diet discipline after the first
> month and examination showed remission of the disease
> after three months. Fifteen patients were said to
> have continued receiving medication for the remaining
> three months of the trial. The document noted that
> all those who volunteered for the experiment now
> appear to have recovered from the disease and have
> returned to their normal life prior to the diagnosis
> of the disease. Prior to becoming permanent secretary
> in the Ministry of Science and Technology in 2001, Dr.
> Nelson who dedicated six years to the research into
> the new drug, worked with the Raw Materials Research
> and Development Council.
>
>
>
>
>
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