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Here is an abstract I found while searching medline....It mentions
celiac testing, confirmation, diabetes, IgA.....
If you want to search medline for free you can do so from my page at:
http://www.mindspring.com/~drbsaks
look under the section "research".....I will post others that I think
are appropriate....
Warm regards,
Brett
Record from database: MEDLINE
Title
Gluten-sensitive enteropathy.
Author
Troncone R; Greco L; Auricchio S
Address
Department of Pediatrics, University Federico II, Naples, Italy.
Source
Pediatr Clin North Am, 43: 2, 1996 Apr, 355-73
Abstract
Gluten-sensitive enteropathy is induced by dietary wheat gliadin
and related proteins in genetically susceptible individuals. Most
evidence suggests that the mucosal lesion represents an
immunologically mediated injury triggered by gluten in the
context of a particular assortment of major histocompatibility
complex genes. The amino acid residues of gliadin and related
proteins responsible for toxicity have not been identified; in
vitro systems are available, but definitive conclusions must rely
on in vivo jejunal challenges. At a conservative estimate,
symptomatic gluten-sensitive enteropathy affects approximately 1
in 1000 individuals in Europe; however, it is now becoming clear
that a greater proportion of individuals has clinically silent
disease, and probably many others have a minor form of the the
enteropathy. In most countries, the clinical presentation has
changed over the past few years coming closer to the adult type
of the disease, and the age of onset of symptoms is shifting
upward. Liver, joint, hematologic, dental, and neurologic
symptoms are increasingly being recognized. Several diseases are
associated the gluten-sensitive enteropathy, such as IgA
deficiency, insulin-dependent diabetes mellitus, and a range of
other autoimmune diseases. Tests based on the measurement of
antigliadin and antiendomysium antibodies have gained success as
noninvasive screening tests; however, the ultimate diagnosis
still is based on the finding of a severe histologic lesion of
the jejunum while the patient is on a gluten-containing diet and
on its disappearance once the gluten is excluded from the diet. A
lifelong, strict GFD is mandatory for celiac children. Among
other long-term problems, an increased risk of intestinal
lymphoma has been reported in patients on a normal
gluten-containing diet.
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