I hope this is the appropriate list for this. I have done a fairly
cursory search of medline on AA(arachidonic acid). I think these may be
the most relevant articles that may allay some fears of AA dietary
intake.
The last article, especially, alludes to some fairly topical results for
this list. I cannot find these results, maybe someone else can. These
articles have been selectively edited. I reckon you should read the full
abstract for your own judgment.
Gary
Brain Dev 19 (3): 165-170 (Apr 1997)
Nutrition and cognitive function
Gordon N
There are many reasons to favour breast feeding, rather than giving
formula feeds, including improved cognition and visual function. For
example breast milk contains docosahexaenoic acid and arachidonic acid,
essential for normal brain development,
and often absent or in short supply in formula feeds.
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Lipids 32 (4): 449-456 (Apr 1997)
Effects of dietary arachidonic acid on human immune response
Kelley DS, Taylor PC, Nelson GJ, Schmidt PC, Mackey BE, Kyle D
USDA, ARS, Western Human Nutrition Research Center, Presidio of San F
Francisco, California 94129, USA.
However, the lack of any adverse effects (by AA) on Immune Response
indicates
that supplementation with AA may be done safely when needed for
other health reasons.
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Lipids 32 (4): 427-433 (Apr 1997)
The effect of dietary arachidonic acid on plasma lipoprotein
distributions, apoproteins, blood lipid levels, and tissue
fatty acid composition in humans
Nelson GJ, Schmidt PC, Bartolini G, Kelley DS, Phinney SD, Kyle D,
Silbermann S, Schaefer EJ
Western Human Nutrition Research Center, ARS, USDA, SAn Francisco,
California 94129, USA.
A 50 day controlled trial with a high AA diet.
After consuming the high-AA diet, the total red blood cell fatty acid
composition was significantly enriched in AA which mainly replaced
linoleic acid.
These results indicate that dietary AA is incorporated into
tissue lipids, but selectively into different tissues and lipid classes.
Perhaps more importantly, the results demonstrate that dietary
AA does not alter blood lipids or lipoprotein levels or
have obvious adverse health effects at this level and duration of
feeding.
Dietary AA had no statistically significant effect on the blood
cholesterol levels, lipoprotein distribution, or apoprotein levels.
Adipose tissue fatty acid composition was not influenced by AA
feeding.
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Lipids 32 (4): 421-425 (Apr 1997)
The effect of dietary arachidonic acid on platelet function, platelet
fatty acid composition, and blood coagulation in
humans
Nelson GJ, Schmidt PC, Bartolini G, Kelley DS, Kyle D
Western Human Nutrition Research Center, ARS, USDA, San Francisco,
California 94129, USA.
The results from this study on blood clotting parameters and in vitro
platelet aggregation suggest that adding 1.5 g/d of
dietary AA for 50 d to a typical Western diet containing about 200 mg of
AA produces no observable physiological changes in blood coagulation and
thrombotic tendencies in healthy,
adult males compared to the unsupplemented diet. Thus, moderate intakes
of foods high in AA have few effects on blood coagulation, platelet
function, or platelet fatty acid
composition.
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Lipids 32 (4): 415-420 (Apr 1997)
A human dietary arachidonic acid supplementation study conducted in a
metabolic research unit: rationale and design
Nelson GJ, Kelley DS, Emken EA, Phinney SD, Kyle D, Ferretti A
Western Human Nutrition Research Center, ARS, USDA, San Francisco,
California 94129, USA.
While there are many reports of studies that fed arachidonic acid (AA)
to animals, there are very few reports of AA feeding to humans under
controlled conditions. This 130-d study was
conceived as a controlled, symmetrical crossover design with healthy,
adult male volunteers.
The results of these studies will be presented in the next five papers
from this symposium.
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