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Date: | Mon, 2 Jun 1997 21:03:58 -0500 |
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Todd Moody wrote:
> Here is a quotation from a web article that has a great deal of
> information on gluten/casein intolerance and autism:
>
> Autism researchers have been intrigued by the fact that a
> PST deficiency can cause the improper metabolism of some
> neurotransmitters (serotonin, dopamine and
> noradrenaline.) It has been known for years that
> autistics often have abnormal levels of serotonin, at
> least as is measured in the blood. but the buildup of
> serotonin may be less significant than another outcome of
> PST deficiency--namely, the effect this deficiency would
> have on the permeability of the intestinal lining.
Very interesting ... There is a reprint you should request from your
univeristy library, here's the citation:
Debas HT, Mulvihill SJ. Neuroendorine design of the gut. Am J Surgery
1991; 161:243-249.
This is a good start to understanding the gut and serotonin. Admittedly
well written for surgeons <TIC>!
This serotonin thing is cool. Did you know that migraine sufferers can
abort an episode by forcing themselves to vomit? Apparently, vomiting
and other GI contractions cause a release of gut serotonin which enters
the brain and somehow arrests the headache. This mechanism may be
related to vasomotor properties of serotonin on the cerebral vessels.
> I would be *very* interested to learn whether the PST enzyme is
> itself sensitive to changes on the insulin/glucagon axis.
> If so, this would be another *major* confirmation of the Ancient
> Wisdom of paleodiet.
I did a paperchase search last night and obtained 33 citations on PST.
Am loking over them closely. Did find a reference to modulation to PST
by quercetin the bioflavanoid from the rutin family. Quercetin
downregulates PST. Will keep you abreast.
Andrew =8-)
--
Andrew S. Bonci, BA, DC, DAAPM
Assistant Professor, Department of Diagnosis
Cleveland Chiropractic College
6401 Rockhill Road
Kansas City, Missouri 64131
(816) 333-7436 ex39
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