<<Disclaimer: Verify this information before applying it to your situation.>> I posted a question about what a elevated IgG could mean if not celiac. The majority of responses said they didn't know but were interested if I found out. Several posts also said it could be a false positive or the other tests could be a false negative. One poster corrected my typing errors. I did find a medline article called: The predictive value of antigliadin antibodies in the diagnosis of non-celiac gastrointestinal disease in children. (authors-Bottaro, Failla, Rotolo, Azzaro, Spina, Castiglione, Patane) A summary follows. I have edited. Recent antigliadin antibody determination has become an important diagnostic tool in coeliac disease. Although this test has high sensibility for the diesease, it is less specific, especially for IgG class, because of its having beeen found in some acute and chronic common intestinal childhood diseases. We studied the behaviour of AGA, IgA and IgG in 234 children affected by various gastrointestinal diseases comparing the results with those obtained in 125 coeliac children and 788 normal children. The intestinal diseases were as follows: irritable bowel syndrome, cow's milk protein intolerance, acute infectious diarrhoea, parasitosis, lactase deficiency, recurrent abdominal pin, cystic fibrosis, chronic constipation, gastroesophageal reflux, intestinal lymphangiectasia, chronic intractable diarrhoea and nodular lymphoid hyperplasia. Our results showed that while IgA were absent in all children studied, with the exception of 3 cases of acute diarrhoea, a moderate percentage of IgG was observed in subjects with cow's milk protein intolerance, acute diarrhoea, irritable bowel syndrome, lactase deficiency, chronic intractable diarrhoea and in a low % of children with parasitosis, intestinal lymphangiectasia and nodular lymphoid hyperplasia. The different behaviour of the two antibody classed could be explained by the fact that IgG were detected in diseases where scattered areas of mucosal damage could allow the permeability of the macromolecules inducing passage of gliadin through the mucosal barrier and immune system-induced antibody stimulation. Thanks for the responses! Susan