<<Disclaimer: Verify this information before applying it to your situation.>> I received over 40 responses to the query about any possible relation between celiac sprue and sulfa. There does not appear to be that significant a relation, at least not in terms of anyone responding being told by a doctor that the two were possibly connected. As to correlation -- many indicated they knew about a sulfa allergy before being diagnosed re. gluten intolerance/CD. There were a few responses who were not allergic to sulfa, and found it very helpful in treating certain conditions. There may be some value in the belief that CD produces greater vulnerability, but that may vary greatly across the CD population. Perhaps the most important response is that those who have had an initial experience have been told that a second could be far more dangerous than the first. Rashes, hives, itching, etc. are the most common symptoms reported. Some respondents indicated Bactrim was the medication they reacted to; one wondered whether Macrodantin was part of the sulfa family. Another wondered if anyone reacted to natural sulfites in food. If anyone wants to comment further on this issue, perhaps it would be best to contact me directly, as this is not an issue to explore further on this list. Thanks for the replies. Raymie