<<Disclaimer: Verify this information before applying it to your situation.>> I have basically been wheat free since the first of the year except for a few setbacks but my question is ....has anyone experienced depression when withdrawing from wheat?? I do feel lots better physically, more energy, no aches and pains etc but depression I don't normally have like I am having now and I can't seem to kick it. My doctor gave me a prescription for zoloft but have not begun taking it as I have not been able to find out if it is gluten free. Does anyone have any ideas or suggestions?? I have tried St. Johns Wort but it lays me right back to where the world could explore and I wouldn't care at all :-/ ~~Katlee in Michigan