<<Disclaimer: Verify this information before applying it to your situation.>> Hi all, I asked a few weeks ago if people were finding that they responded less fully to medications than non-celiacs. First of all I asked my GI about this and he said it was possible but unlikely and also that different meds absorb in different places of the gut, so it might depend on what you were taking as to whether it might be malabsorbed. Several clinic GP's have told me it is a possibility. The list responses I got were these: -decreased absorption of opiates/tylenol for migraines, also bad reaction to medications used during surgery (opiate malapsorption reflected by drug taking longer to work than for other people) -non CD spouse can get by with half the meds of CD spouse -celiac child doesn't respond as quickly to antibiotics as non-celiac child -novocaine has to be reinjected every 10 minutes during dental work as it wears off quickly Specific solutions to migraine included Imitrex nasal apray or injection as this bypasses the gut *** don't know if Imitrex is GF I've had all of the above happen with meds. I usually need at least 2 shots just to get a filling started at the dentist (can't explain this as it's subdermal and not gut absorbed). Both tylenol and imitrex (oral) take longer to have an effect. Antibiotics unless taken in injectable form (some but not all are available in Canada, mostly in ER) don't have much effect. I had several suggestions for causes of migraines (thanks!) but I won't post them here as they aren't directly CD related (except mine can be brought on by eating gluten esp MSG). There is an online migraine news group if anyone wants more detail on headache treatments. It's under alt.support.headaches.migraine and discussions run from older rememdies to the newest. Just a note, the above info came from 5 separate posts, so it's not an extensive survey, but interesting as a possibility. Thanks again to everyone for suggestions and info! Lissy [log in to unmask]