<<Disclaimer: Verify this information before applying it to your situation.>> Summarization of Celiac Disease and IGA 1. Definitely has wheat allergy problem from IGA deficiency. 2. Antibodies are not showing up in her blood, after so ong, but are at the cellular level, ie:the cell carries the toxicity. Was told to contact a Homeopath to "clean up". 3. Secretory IGA def. cannot be remedied. 4. Granddaughte has IGA def and Celiac. It is not uncommon in celiacs for test to read "false". 3 tests were negative for CD only 1 was positive. Most MDs are not aware of this fact & you can still have CD. 5. 100% IGA deficient causes false nega-tives on endomysial antibody test. 6. How is it that people of Northern European ancestry have the majority cases of CD. Must be a connection somewhere to Eastern European ancestry. Notice surnames of posts. 7. Celiacs can have IGA deficiency but other components of the celiac screen must be positive. With mixed results, you may be gluten-sensitive. Different? but same symptoms. 8. Has 9 children, has observed: 4 children had immunizations. They are all celiacs & IGA deficient. In hospital frequently, sometimes near death's door. Next 5 had no immunizations no hayfever, asthma, ear infections except in 2 (mild) Wondering if others have found immunization hurt celiacs rather than help. This brings up a new discussion (online answers only) 8. Someone diagnosed with IGA def. thought that she had IBS. as bacterial overgrowth, malabsorption, migraines, joint pain, constant diarrhea and severe cramping after every meal. Sounds like this person needs a celiac profile done. Says toxins drag you down, making you more receptive to bacteria. 9. Theory: It is absolutely certain that Celiac i not 100% genetic. Documented by identical twins. One has it, one doesn't. It is also documented that there is no genetic propensity. Theory: For someone with the right immunological set-up, an infection by a virus which, to the immune system resembles gliadin is detected, may be the triggering mechanism. Next time, gliadin is detected, the immune system believes it is under attack and responds accordingly. Daughter had refractory sprue and was treated with cyclosporine and is now healthy. 10. On the other hand, some believe that any serious disease or major surgery can cause trauma to the body and glands. After the trauma, your system changes. Many were diagnosed after such incidences. People have gotten Chronic Fatigue Syndrome and Multiple Chemical Sensitivities, leaky gut, malabsorption syndrome after having had major surgery, mononeucleosis, or cytomegla virus. In summarizing, to shorten this, most people believe there is a connection, having Celiac Disease and having an immunoglobulin A deficiency but not all of us have both. Rosalie Miracles do Happen!