<<Disclaimer: Verify this information before applying it to your situation.>> I received this message from Jill of North Carolina, that I thought I should pass on as a warning. "Too much B6 can cause irreversible peripheral nerve damage. I have had tons of neurodiagnostic tests because my nero symptoms have not gone away in two years GF. Each time I see a neurologist at Univ. of NC-Chapel Hill they ask to see my vitamin bottles. I take Freeda Ultravites which lists the toal amount for 3 tablets daily, not per tablet. For 3 tablets the total shows 50mg B6. They all totally wig out and almost scream that that is too much B6. I have to calm them down and point out that I only take on and occ. 2 tabs daily. They see more b6 toxicity and peripheral nerve damage than deficiencies. On the other hand, I have chronic thiamine (B1) deficiency which does cause "brain fog" as well as peripheral lesions. Hope this helps; I think we need to caution list members to not take megadoses of B6 for depression without getting blood levels first." As a postsscript to this, I should mention that the sublingual B vitamin that I mentioned in my post on B6 research just has 2 mg. of B6 per dosage, so its not likely to be excessive. My husband's doctor recommended a capsule supplement which was 200mg. daily, and the reason for the larger dose was that he felt that because of the malabsorption problem he needed larger doses in order to make sure that he really got something out of it. Cordially, Cyndee Burgess Reserve, New Mexico