An article of interest to get you started. It reviews other work in the area. Published in the Journal of Clinical Pharmacology 1994:34:158-166. It is entitled "Clinical Pharmacology of Pancreatic Enzymes in Patients with Cystic Fibrosis and In Vitro Performance of Microencapsulated Formulations." This article outlines the problems CF patients have w/ pancreatic function and discusses past and present therapy. It also compares many brands of pancreatic enzymes. The amount of actual enzyme activity versus the labeled activity was reported. Most preparations have more enzyme activity than is stated on the label, sometimes as much as 50%. Also they tested enzymes for activity after they had soaked in simulated gastric fluid(SGF). Most preparations did pretty well, but one formulation (a generic by Rugby) had ZERO activity after one hour in SGF. This article did not address resent problems and reports of colonic strictures associated with mega doses of high dose enzyme formulations. Although this article was published recently, most of the work writing it was probably done before these problems became a hot topic. This paper was funded by the CF Foundation and NIH. The address for reprints is: Leslie Hendeles, PharmD, University of Florida Health Science Center, P.O. Box 100486, Gainsville, FL 32610-0486.