<<Disclaimer: Verify this information before applying it to your situation.>> See the earlier posts on Vasotec and/ or Merck. My post of June 29 discusses the starch in Cardizem. I got a call back from Hoescht Marion Merrill Dow (800-362-7466, John Wokte) about the gluten status of Cardizem CD, the time release form of this calcium blocker. I should be getting this in writing. I didn't push on thecorn/ wheat options for the starch this time but suspect that may show up in what they put in writing. Because of the FDA's control over the ingredients in prescription drugs, you can actually find out something about starch content. Details follow, but for me it looks like there's so little (carbohydrate) starch in the 180 mg dose capsules I take that, even if the protein impurity in that starch were all a toxic gluten, then the amount is so much smaller than any daily amount shown to cause damage in biopsed celiacs. (I can't rule out the possibility that some people may have a "Type I hypersensitivity reaction" (IgE) to gluten with the short term vomiting or diarrhea but I doubt celiac damage.) Starch in cardizem CD (180 mg. dose): ingredient list (Physician's Desk Reference): 11 listed in order of decreasing amounts with sucrose 7th followed by starch 8th. There's 60 mg of sucrose in these pills. It's present as the core of the time release seeds --the 180 mg of drug is coated on all these tiny cores and starch is used as a binding agent in this coating. The amount of starch is actually much less than the 60 mg. of its list neighbor sucrose. Whether down by 10 or even more I didn't bother to find out due to the following. 100 mg. toxic gluten/day for a month has been shown to cause some intestinal damage in Catassi et al (study used controls, as I recall). How much might be in (worst case) 60 mg of wheat starch? Starch is made by washing out the protein part of the grain flour. The protein portion of wheat is roughly 10% so 6 mg. here. Even if the washing process only gets 90% of the protein out that leaves just 0.6 mg of wheat protein (Washing used to meet celiac standard abroad must be much better than this because daily consumption of starch is likely hundreds of grams, 100 or more as much.) Again, for worst case say it's all toxic. (Don Kasarda may be able to refine these wheat numbers, indeed even lower them significantly. I can also lower the original worst case 60 mg. amount by calling Hoescht again.) But can someone show us a study that even an overestimated 0.6 mg. of toxic gluten a day had a measurable effect on celiacs? In the meantime, while waiting the letter from Hoescht that may clarify their ability to switch wheat starch for corn starch, I'll continue taking the Cardizem. The Vasotec situation may involve much more starch. If it does and they stll claim the wheat substitution ability, get it in writng and contact the FDA. Kemp Randolph Long Island