<<Disclaimer: Verify this information before applying it to your situation.>> I am researching some of the issues raised in Prof. Luigi Greco's article "From the Neolithic Revolution to gluten intolerance: benefits and problems associated with the cultivation of wheat" from an anthropological/archaeological perspective. Profesor Greco says there should be a higher rate of CD among those people whose ancestors come from areas in Europe that were the last to add cultivated wheat, barley, and oats to their diet. Domestication of these gluten-rich grains began in the Fertile Crescent about 10,000 years ago, and gradually spread, eventually reaching places like Ireland and Scandinavian only about 4,000 years ago. Does anyone know of any supporting evidence for Prof. Greco's theory? The references he cited seemed inconclusive about whether there really was a geographic variation in incidence rates of CD. Also, it seems that a simple test of the theory might be to look at people from parts of the world where gluten containing grains were not commonly eaten -- which means most of Asia, Africa, and South America -- and see what the incidence of CD is for those who move to Europe or North America and adopt a high gluten diet. It should be very high. Does anyone know of evidence for this? Information, suggestions, or comments would be greatly appreciated. For those who haven't read Prof. Greco's article, it is available as a file on this LISTSERV titled CELIAC CUL-WHT. Thanks, Chris Neurath DeKalb, New York email: [log in to unmask]