<<Disclaimer: Verify this information before applying it to your situation.>> I've recently had a curious situation somewhat resolved, and wondered what the collective mind of the Celiac Mailing List thinks of it. My son, Eli, will be two in July. We figured out that he might be celiac about a year ago, and had the igA igG and anti-endomesial blood tests conducted, but they were sent to the wrong laboratory, with negative results on all tests. Eli, however, thrived and improved on the GF diet, so we kept him GF for the last year. We decided to revisit the issue again, challenged him with Wheat, Oats, Barley, Millet and Rye for three weeks and re-did the blood tests. Eli tested positive on igA, igG and negative on the anti-endomesial test. Our doctor (a pediatric gastroenterologist who's quite familiar with CD) concluded - "you've done a good job keeping him gluten free - we'll have to repeat this test in a year." Quite obviously there are two possibilities: 1) This is an allergy, and not CD, or 2) This is CD, but for some reason, including the age of the subject (less than 2) the anti-endomesial test is a false negative. Are there any possibilities I've overlooked? Can anyone direct me to anything other than the recent discussion of blood testing on this mailing list which would shed some light on this situation? If my wife and I were _really_ curious, we'd have another challenge and a biopsy, but a) we're not really wild about having a biopsy done on an almost 2 year old and b) we're content to run a GF diet for Eli for another year. Another kink in the scenario - Eli will have a little brother or sister born next month - at least this time his monther and father will know what to look for when we get the gassiest baby in Maryland (which was how Eli was described by some of our friends). John Cornell Rockville, MD [log in to unmask]