<<Disclaimer: Verify this information before applying it to your situation.>> What is a safe dose of dapsone? The most common side effects of dapsone are on the blood cells specifically the red cells It can break them up ( hemolysis) or if can interefere with their ability to carry oxygen. While there are other side effects ( skin rash, nausea, liver dysfunction bone marrow effects theese are rarer) The lowest dose that controll the rash is the best dose. Adhereing to a gluten free diet will reduce the requiremnet over about 2 years to the point that many peolpe will be able to stop it altogether, Need to be a strict diet. While some one is on dapsone they need to have regular blood counts and liver blood tests to check for side effects. There are other drugs that are sometimes used but these also have their side effects. Joe Muuray Not specific medical advice but an educational service- consult your physician.