I believe that the problem is that the body produces AGEs in response to eating food that is cooked at high temperatures. AGEs in turn cause the body to produce proteins that cause inflammation. These AGEs are formed more readily and are more damaging when blood glucose is high because of eating sugars or because of diabetes). Since in our Paleolithic ancestors diabetes was probably not much of a problem neither was AGEs. Besides diabetes (Type II) and heart trouble are diseases of "old" age (over 30) and seldom affect procreation. So our ancestors could survive and appear to live well on meat cooked on a fire. Modern people who live to old age have a longer time to accumulate damage from AGEs. For those modern people also have been exposed long term to grains and sugars and have high blood glucose problems AGEs may be a big problem. I have been thinking about a theory, explained in "The body's many cries for water", that high cholesterol levels are a natural response to inflammation and other damage to the walls of the arteries. Even some paleo eaters still have high cholesterol. Modern medicine just treats the cholesterol without understanding why it is high but the AGEs could be the underlying cause. I wonder if the paleodiet that still includes foods cooked at high heat may not address this high cholesterol problem. Any comments that could point out flaws in my thinking or could clarify this matter will be appreciated here. Michael ----- Original Message ----- > "These are substances that are forming spontaneously in our body from > glucose reactions," Vlassara said. "The higher the glucose is, the higher > the products will be. Diabetics (news - web sites) have a lot more, and they > are highly toxic."