"It seems to me that the Celebrex has a kind of reverberation effect. When I take it, my arthritis feels worse when the Celebrex wears off than it did before I started taking it. It's been about 6 days since I stopped, and I feel better than I did on days 1,2, & 3." I have noticed this as well and I would say it's probably due to some prostaglandin feedback mechanism in the body or something along those lines. I haven't explored nsaid's in detail but i'd imagine whatever is being inhibited by them to kill pain tends to be very DE-inhibited to an even greater extent once their effects wear off. It's gotten to the point where I haven't taken celebrex, Vioxx, or any other NSAID in 6 months despite my Dr. giving me a free supply because another thing I have noticed is that when I take them I invariably get weak and start to lose muscle size and strength. Being an athlete I find this unacceptable so now I just take a lot of fish oils and pay strict attention to food selection. I have noticed that dairy products were/are a big contributor to my arthritic symptoms even though I feel perfectly fine when consuming them. Other foods make me feel like an absolute wreck but don't seem to affect my joints. Curious whether anyone else with arthritis has noticed anything along these lines? _________________________________________________________________ Join the world’s largest e-mail service with MSN Hotmail. http://www.hotmail.com