<<Disclaimer: Verify this information before applying it to your situation.>> List members: I'm searching for help.; I searched the archives but couldn't find an answer to this one. I've been ill for the past year and a half (lost 60 pounds, muscle and joint ache, nausea and vomiting, etc.) to the point that I've been in the hospital twice. After tons of neg. tests, my doctor finally did blood work for CD; it came back positive and he put me on a gluten free diet. I improved significantly. They then asked me to do a gluten challenge so they could do a biopsy; I became very sick, lost more weigh, and ended up in the hospital again. The biopsy just came back negative, and I was told by the gi that although my intestines are inflamed, there is no villi damage; so therefore, I do not have CD. I should not restrict my diet as I need the carbs from a gluten containing diet to feed my very diminished body. Before I start searching for whatever is wrong, can someone explain how you can have positive blood work and relief of symptoms on a gf diet, but a neg. biopsy. Thanks for your help.