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RAW-FOOD  April 1997

RAW-FOOD April 1997

Subject:

Re: metabolic vs. digestive enzymes- articles

From:

"Jeffrey S. Novick" <[log in to unmask]>

Date:

Sat, 19 Apr 1997 00:40:22 -0500

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (22 lines)

An article of interest to get you started. It reviews other work in the
area.  Published in the Journal of Clinical Pharmacology
1994:34:158-166. It is
entitled "Clinical Pharmacology of Pancreatic Enzymes in Patients with
Cystic Fibrosis and In Vitro Performance of Microencapsulated
Formulations." This article outlines the problems CF patients have w/
pancreatic function and discusses past and present therapy. It also
compares many brands of pancreatic enzymes. The amount of actual enzyme
activity versus the labeled activity was reported. Most preparations
have more enzyme activity than is stated on the label, sometimes as much
as 50%. Also they tested enzymes for activity after they had soaked in
simulated gastric fluid(SGF). Most preparations did pretty well, but one
formulation (a generic by Rugby) had ZERO activity after one hour in
SGF. This article did not address resent problems and reports of colonic
strictures associated with mega doses of high dose enzyme formulations.
Although this article was published recently, most of the work writing
it was probably done before these problems became a hot topic. This
paper was funded by the CF Foundation and NIH. The address for reprints
is: Leslie Hendeles, PharmD, University of Florida Health Science
Center, P.O. Box 100486, Gainsville, FL 32610-0486.

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