Instead of glutamic acid at position number six on the polypeptide
hemoglobin chain as it should be, valine is inserted in its place.  This
changes the hemoglobin to *HbS* (Hb=hemoglobin and "S"  is for Sickle
Cell) instead of the normal Hemoglobin A.  Some victims carry two sickle
cell genes instead of one and are therefore homozygous for the sickle
cell mutation.  They are more prone to sickling because every single red
blood cell of the homozygote carries the sickle type of hemoglobin.
Therefore, these unfortunate ones suffer through many painful crises
of sickling with hemolysis of the red blood cells and anemia.  In
contrast, if the individual is heterozygous (carrying only one sickle
cell gene) then only about forty percent of the hemoglobin is of the
Sickle type.  Most of the Hemoglobin is the normal type that does not
sickle.  Consequently, the blood dyscrasia of those with
only one damaged gene is easier to deal with.  When the HbS type of
hemoglobin is under-oxygenated it will clump then polymerize, forming
long chains, which transform it into a gel like substance.  This
causes a distortion of the red blood cells, from which the disease gets
its name. This process is known as "Sickling."  The sickling produces two
major problems. First, the continual sickling damages the red blood
cells, destroying many.  This causes the Anemia.  Second, the misshapen
and less flexible red blood cells get stuck in small blood cells,
clogging arteries all over.  Nutrients can not get through
to cells and metabolic wastes can not be carried away from cells.
Consequently, the tissues that depend on those blood vessels for
nutrients and excretion deteriorate and finally many tissue cells die
from lack of nutrition and the accumulation of wastes.  The low oxygen
tension which causes the hemoglobin "S" to gel, can be reversed by
re-oxygenating the cells.  Then the sickling of the red blood cells
stops.  But, the cell membrane of the red blood cells is damaged by this
continual sickling and unsickling, becoming weak, and frayed.  Finally
the cell succumbs.  In spite of the propensity to sickle, those who are
homozygous and have no normal HbA at all, can still help themselves by
living in accord with natural law, and their own individual limitations.
Even though the homozygous ones, without a knowledge of Hygiene, may in
the end finally develop full blown sickle cell Anemia, they are
nevertheless *not* always in crisis.  It takes some enervating factors or
influences to precipitate a crisis.  This is important because it is easy
to learn how to avoid substances, factors and influences that lower nerve
energy. Since the causes of Sickle Cell Disease are usually not removed
or corrected under medical care, the disease is long and drawn out, with
painful crises interfering with and spoiling what could be a happy life.
Ischemic pain is one of the most excruciating types of pain anyone could
have and it is caused by the lack of blood to the tissue or body part due
to the clogged arteries.  Naturally, tissues are injured and death of
cells occur.  Gradually organs are spotted with dead tissue and
function is crippled proportionately to the destroyed cells. It is my
opinion that the sickling of cells can be abolished, or reduced in
number, even in the homozygote whose cells contain only HbS -- no normal
HbA at all, by avoiding all known triggers that are associated with
sickling.  Sickling is known to occur when (1) the oxygen tension is low,
(2) when the homozygote has an infection or an acute illness, (3) when
dehydrated, or (4) when acidotic.  All of these triggers can be avoided
by Hygienic living! If the triggers or causes of the sickling are avoided
then, voila! No symptoms, no death of red blood cells or organ tissues,
no anemia, and no ischemic pain! Therefore, a feeling of well-being
replaces pain and degeneration while at the same time the chances of a
reverse mutation increase tremendously! If Sickle Cell disease were
traced to its origin, in all likelihood we would discover that it began
with a mutation caused by the poor diet and lifestyle of the African
American. It is important to note that an aplastic crisis during which
the bone marrow actually stops forming new blood cells, seems to be
triggered by infections and folic acid deficiency, or both.  No diet
better supplies an abundance of folic acid that the Hygienic one, which
includes raw fruits and vegetable salads every day. Individuals with the
sickle cell trait now can have hopes of living past the age of thirty.
Those who now live beyond the age of thirty, with supportive medical
treatment, could probably live a fully productive, painless life by
adopting a Hygienic lifestyle.  It is a certainty that both the
homozygous and heterozygous individual for the sickle cell trait can at
least be helped with Hygienic care.  With the uncooked Hygienic diet
furnishing all the nutrients needed, including folic acid, and with mild
aerobic exercises keeping the red blood cells well oxygenated, in
addition to all the other requisites of life, the sickling of red blood
cells will certainly diminish if not cease altogether.  The individual
will not be acidotic and will not, or rarely ever develop an infection.
Consequently, nutrition in its grand total meaning will be superb.  Once
the Hygienic life is begun and persisted in, everyday the health of the
individual will improve.  Consequently, there will be fewer and fewer
crises of sickling.  By living to avoid sickling, the detrimental effects
of sickling such as clumping of the cells, the fragile and dying red
blood cells, and anemia will be a thing of the past.  Right living and
good nutrition will save good normal cells all over the body, and will
greatly extend the life of one with a genetically inherited disease.
The heterozygote is even easier to care for than the homozygote.  Their
red blood cells do not sickle when the oxygen tension is low.  These
people do not suffer with hemolysis of the red blood cells, nor become
anemic.  You can be certain the heterozygote will be healed.

HEMOPHILIA
Hemophilia is another serious "genetically determined"  hereditary
disease. Being an X-linked recessive trait it occurs in homozygous
females and in males. The disease also manifests in heterozygous females
when the unaffected gene has been inactivated in some biochemical manner.
Fortunately for the hemophiliac, not all cases are symptomatic.
Therefore, it is almost certain that the disease is amenable to Hygienic
care.  Hemophilia manifests clinically only when the Factor VIII levels
are less than one percent. Those with Factor VIII levels from 1 to 25
percent are not too bad off either.  They have no symptoms except when
traumatized.  Then they merely bleed longer than normal, but they do not
have the spontaneous bleeding of those seriously affected. It is
significant that there are not only one, but various types of mutations
that have been found in hemophiliacs.  The different types of genetic
lesions so far discovered are classed as, 1) deletions, 2) the creation
of stop codons, 3) and splicing errors.  A stop codon calls a halt to the
formation of a particular protein, leaving it unfinished and
metabolically nonfunctional.  It is also significant that in ten
percent of those with hemophilia the levels of factor VIII are normal
when tested in the laboratory, but by bio-assay the coagulant activity is
low. Why is the above knowledge significant?  First, not all those with
the inherited trait develop the disease because there are too many
different types of mutations. Furthermore, these gene changes may or may
not cause the disease.  In addition, clotting is a complicated series of
biochemical changes, so there coulds be thousands of other reasons why
clotting does not take place or is interfered with, or that coagulant
activity is low.  Another factor in favor of recovery is the strange fact
that although the coagulation time is prolonged, the bleeding time is
normal in all hemophiliacs.  There is no shortage of thrombocytes which
plug a minute puncture wound.  And this helps stop bleeding even of
larger wounds because the arteries still respond to damage by contracting
at the severed edges to help prevent a loss of blood.  This is
significant!  Not all factors which are designed to curtail bleeding
are non-functioning.  Additionally, prolonged coagulation time is not
solely due to a lack of Factor VIII, and excellent nutrition can make up
for low Factor VIII levels.
...
o.b.t.s.j. ([log in to unmask])