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Subject:
From:
Ingrid Bauer <[log in to unmask]>
Reply To:
Raw Food Diet Support List <[log in to unmask]>
Date:
Tue, 4 Jun 2002 02:00:50 -0700
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 Some indications that some  common practices in conventional farming could be daamaging to one's  health 
jean-claude

:] important new study shows round-up unsafe for human exposure]


> 
> 
> The study below  shows effect of glyphosate on cell cycle controls.The
> implications on human health are profound. Such studies should not be
> ignored by regulators!
> Chem Res Toxicol 2002 Mar;15(3):326-31       Pesticide Roundup Provokes
> Cell Division Dysfunction at the Level of CDK1/Cyclin B Activation.
> 
>    Marc J, Mulner-Lorillon O, Boulben S, Hureau D, Durand G, Belle R.
> 
>    Station Biologique de Roscoff, Universite Pierre et Marie Curie (UFR
> 937), Centre National de la Recherche Scientifique (CNRS, UMR 7127), BP
> 74, 29682 Roscoff Cedex, France.
> 
> To assess human health risk from environmental chemicals, we have
> studied the effect on cell cycle regulation of the widely used
> glyphosate-containing pesticide Roundup. As a model system we have used
> sea urchin embryonic first divisions following fertilization, which are
> appropriate for the study of universal cell cycle regulation without
> interference with transcription. We show that 0.8% Roundup (containing 8
> mM glyphosate) induces a delay in the kinetic of the first cell cleavage
> of sea urchin embryos. The delay is dependent on the concentration of
> Roundup. The delay in the cell cycle could be induced using increasing
> glyphosate concentrations (1-10 mM) in the presence of a subthreshold
> concentration of Roundup 0.2%, while glyphosate alone was ineffective,
> thus indicating synergy between glyphosate and Roundup formulation
> products. The effect of Roundup was not lethal and involved a delay in
> entry into M-phase of the cell cycle, as judged cytologically. Since
> CDK1/cyclin B regulates universally the M-phase of the cell cycle, we
> analyzed CDK1/cyclin B activation during the first division of early
> development. Roundup delayed the activation of CDK1/cyclin B in vivo.
> Roundup inhibited also the global protein synthetic rate without
> preventing the accumulation of cyclin B. In summary, Roundup affects
> cell cycle regulation by delaying activation of the CDK1/cyclin B
> complex, by synergic effect of glyphosate and formulation products.
> Considering the universality among species of the CDK1/cyclin B
> regulator, our results question the safety of glyphosate and Roundup on
> human health. 
> 
> 

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