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Subject:
From:
Blake Graham <[log in to unmask]>
Reply To:
Raw Food Diet Support List <[log in to unmask]>
Date:
Sat, 24 Nov 2001 13:49:55 +0800
Content-Type:
text/plain
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From: http://216.118.123.225/health/b12.html

"Symptoms

Neurological Symptoms
Neurological symptoms are the biggest worry in B12 deficiency because they
can be irreversible. However, if caught early enough, they can be reversed
in many cases.

One theory of why nerve problems occur in B12 deficiency is from a lack of
methionine (from B12 not converting Hcy back into methionine) which creates
a lack of S-adenosylmethionine (SAM).35 SAM is required for the production
of phosphatidylcholine36 which is part of the myelin (the fatty material
that insulates many nerves). Phosphatidylcholine improves nerve
transmission.36

Another theory is that the altered nerve function of B12 deficiency is
possibly due to the body's inability to convert methylmalonyl-CoA (a 3
carbon molecule) to succinyl-CoA (a 4 carbon molecule). This inability
results in a build up of propionyl-CoA (a 3 carbon molecule). Fatty acids
are normally made by adding 2 carbons at a time to an even numbered carbon
molecule. In an overabundance of 3 carbon molecules, large amounts of
unusual 15-carbon and 17-carbon fatty acids could be produced and
incorporated into nerve sheets, causing altered nerve function.103

Early Signs of B12 Deficiency
According to Crane et al.18 (1994, USA), the usual vegan patient has no
clinical symptoms or signs of inadequate B12. Early manifestations are
unusual fatigue, faulty digestion (no appetite or nausea) and loss of
menstruation. Other symptoms are nervousness, numbness and tingling of the
hands and feet, mild depression, striking behavioral changes, paranoia,
hyperactive reflexes, fever of unknown origin,18 frequent upper respiratory
infections,19 impotence, impaired memory,49 infertility,55 sore tongue, and
diarrhea.60"

Blake

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