Calorie restriction lifespan experiments have been
done in single cell organisms,flies to primates.
A groundbreaking fasting study shows a greater
effect on cell health,regardless of caloric intake.
Health of organisms seems to be related to lower
levels of insulin/gluclose and higher levels of ketones.
Ketogenic diets do this(most low carbers can confirm this).
Calorie restriction more so (Thomas N Seyfried cancer studies).
Interrmitting fasting the most (without resricting cal).
Frequency of gluclose ingestion is a greater cause of
impairment than quantity.(A healthy organism seems to
repair stress damage from intake of nutrients)
"A 48hr fast elevated ketone levels to a point that
repaired mitochondial damage due to insulin deficiency"
BM