Found this article that demonstrates how different genotypes respond
differentially to diets. Love their caution at the end to check people's
allele's before recommending a diet. From their finding I can deduce that I
must be among those that do not possess the APOE4 allele insofar as my body
responded horribly to the lowfat approach.
1: Metabolism 2002 Jul;51(7):853-8  Related Articles,  Links

Effects of apolipoprotein E genotype on dietary-induced changes in
high-density lipoprotein cholesterol in obese postmenopausal women.

Nicklas BJ, Ferrell RE, Bunyard LB, Berman DM, Dennis KE, Goldberg AP.

Department of Medicine, Division of Gerontology, University of Maryland
School of Medicine, and the Geriatric Research, Education and Clinical Center
(GRECC), Baltimore VA Medical Center, Baltimore, MD, USA.

Lipid responses to a dietary intervention are highly variable between
individuals. Part of this variation may be accounted for by individual
differences in lipid-regulating genes that interact with diet to induce
changes in lipoprotein metabolism. This study determined whether
apolipoprotein E (APOE) genotype affects lipid responses to a low-fat,
low-cholesterol diet in obese, postmenopausal women. Body weight and
lipoprotein lipid responses to a 10-week, dietary intervention (American
Heart Association [AHA] Step I) were compared in 61 women with the APOE 2/3
and APOE 3/3 genotype (APOE4-) and 18 women with the APOE 3/4 genotype
(APOE4+) of a similar age, body composition, and maximal aerobic capacity.
Body weight decreased by 2% in both groups, but changes in body weight
correlated only with changes in low-density lipoprotein-cholesterol (LDL-C)
(r =.27, P <.05). The dietary intervention decreased total cholesterol and
LDL-C to a similar degree in both genotype groups. However, APOE4- women
decreased high-density lipoprotein-cholesterol (HDL-C) by 17% +/- 11% and
increased triglycerides by 20% +/- 41% in response to the diet, while APOE4+
women had a smaller decrease in HDL-C (-8% +/- 12%) and no change in plasma
triglyceride. These group differences were significant for HDL-C (P <.01) and
approached significance for triglycerides (P =.08). Moreover, APOE4- women
decreased HDL(2)-C by 32% +/- 45%, while APOE4+ women increased HDL(2)-C by
12% +/- 62% (P <.01 between groups). It may be prudent to genotype older
women before initiating low-fat diet therapy, as those with the APOE4 allele
benefit the most, while the lipid profile could worsen in women without the
APOE4 allele. Copyright 2002, Elsevier Science (USA). All rights reserved.

Namaste, Liz
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