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A new study shows chromosome aberrations in peripheral blood lymphocytes in
children with CD who have not yet begun a gluten-free diet. This is
interesting. Previously on the List, I posted articles on free radical
damage caused by gliadin, in vitro, and on selenium in which, selenium, an
important antioxidant, and other antioxidants are shown to be deficient in
CD patients. It was shown that even in NORMAL blood serum, gliadin
promotes IgE, IgG and free radicals. Free radicals have been demonstrated
to cause chromosome damage in cells which can lead to the onset of
cancers. Antioxidants neutralize free radicals and are thought to reduce
cancer risks. This new study tends to confirm the free radical role of
gliadin in vivo, i.e. in actual live patients.
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A Role For Antioxidant Therapy in CD?
26 Jun 2003
http://maelstrom.stjohns.edu/CGI/wa.exe?A2=ind0306d&L=celiac&O=D&P=9294
Selenium and CD - Introduction, Part 1, Part 2
2 Aug 2003
http://maelstrom.stjohns.edu/CGI/wa.exe?A2=ind0308a&L=celiac&O=D&P=5736
http://maelstrom.stjohns.edu/CGI/wa.exe?A2=ind0308a&L=celiac&O=D&P=5850
http://maelstrom.stjohns.edu/CGI/wa.exe?A2=ind0308a&L=celiac&O=D&P=5960
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J Pediatr Gastroenterol Nutr. 2004 Feb; 38(2): 177-180
Gluten-Free Diet Has a Beneficial Effect on Chromosome Instability in
Lymphocytes of Children With Coeliac Disease.
Kolacek S, Jadresin O, Petkovic I I, Misak Z, Sonicki Z, Booth IW.
Children's Hospital Zagreb, University of Zagreb Medical School, Zagreb,
Croatia; Department of Statistics, Zagreb Medical School, Zagreb, Croatia;
Institute of Child Health, University of Birmingham, Birmingham, United
Kingdom.
SUMMARY: OBJECTIVES Children with coeliac disease (CD) have an increased
number of chromosome aberrations in peripheral blood lymphocytes. Whether
genetically determined or a secondary phenomenon in CD, chromosome
abnormalities may be involved in the predisposition to cancer in CD
patients. The aim of the study was to follow a group of children with CD in
whom the initial frequency of chromosome aberrations at diagnosis was known
and to measure the same variable after a minimum of 2 years on a gluten-
free diet.METHODS Chromosome aberrations in peripheral blood lymphocytes
were determined in 17 patients with CD, before and after at least 24 months
of a gluten free diet (mean, 33 months), and in 15 healthy children. The
differences in the frequency of aberrations were analyzed by Mann-Whitney U
test and Wilcoxon matched-pairs signed-ranks test.RESULTS Twelve patients
adhered to the diet and had a significantly lower frequency of chromosome
aberrations than did 5 patients not following the diet (0.16% v 1.2%; P =
0.03), whereas at presentation there had been no difference (1.54% v 1.2%;
P = 0.09). The frequency of aberrations at follow-up in patients who were
diet adherent was significantly lower than at presentation (1.54% v 0.16%;
P = 0.02) and remained unchanged in patients who were not diet adherent
(1.2% v 1.2%; P = 1). After at least 24 months of a gluten-free diet,
children with CD did not differ from healthy control subjects (0.16% v
0.27%; P = 0.54), whereas children not following the diet had an increased
frequency of aberrations (1.2% v 0.27%; P = 0.05).CONCLUSIONS The frequency
of chromosome aberrations in peripheral blood lymphocytes of patients with
CD decreased significantly on a gluten-free diet. We conclude that genomic
instability is a secondary phenomenon, possibly caused by chronic
intestinal inflammation.
PMID: 14734880 [PubMed - as supplied by publisher]
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