<<Disclaimer: Verify this information before applying it to your situation.>>

It is clear by a number of postings on this List that some people exhibit 
an extreme sensitivity to small traces of wheat gluten.  Reaction times, 
often within minutes, are more suggestive of an allergic reaction to wheat 
or gluten rather than a celiac disease immune response to gluten.  This 
topic has been discussed in numerous past posts to the Celiac List.  Some 
Listers might be skeptical of those who go to extremes looking for "hidden 
gluten".  When mere traces of peanut products can lead to lethal 
consequences in those with peanut allergy, it should be clear and readily 
acknowledged, by all, that trace amounts of wheat or gluten can, likewise, 
have serious health effects in some individuals.  One study 
found "approximately 13.5 microg of wheat protein can elicit a systemic 
adverse reaction in highly sensitive, wheat allergic individuals."  
Increased intestinal permeability and hypochlorhydria due to celiac 
disease often lead to increased sensitivities and allergies to a variety 
of foods.  Wheat and gluten are not exceptions.  Both celiac disease and 
wheat/gluten allergy can exist together in individuals.

Fortunately, I am not among those with such extreme gluten sensitivity.  
Those of us not so sensitive should have no guilt about enjoying oats or 
einkorn or other foods which might contain small traces of gluten.  Those 
who are extremely sensitive to wheat or gluten should not impose their 
misfortunes upon the eating preferences of those celiacs who are not so 
ill disposed.  Likewise, respect for those who are so sensitive is due.

I was curious as to why those who have extreme wheat/gluten sensitivities 
don't seem to respond positively to specific tests for wheat allergy.  
Some List posters have stated that skin prick tests were negative for 
wheat allergy.  I did some investigating and found that skin prick tests 
have been a poor predictor of wheat allergy.  Specifically, skin prick 
tests with water/salt soluble wheat proteins are unreliable.  However, 
skin prick testing specifically utilizing purified omega-5 gliadin is a 
reliable test for some fast acting forms of wheat allergy, a relatively 
recent discovery.  Those of you with extreme wheat/gluten sensitivity may 
wish to have an omega-5 gliadin test to confirm their sensitivity is due 
to an allergic reaction to wheat as opposed to a celiac disease response 
to gluten.

Below are citations to abstracts of some relevant wheat allergy articles:

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Int Arch Allergy Immunol. 2005 Nov;138(3):257-66. 
Different profiles of wheat antigens are recognised by patients suffering 
from coeliac disease and IgE-mediated food allergy.
Constantin C, Huber WD, Granditsch G, Weghofer M, Valenta R. 
< http://dx.doi.org/10.1159/000088727 >

Ann Allergy Asthma Immunol. 2004 Jul;93(1):98-100.
Systemic urticaria in an infant after ingestion of processed food that 
contained a trace quantity of wheat.
Matsumoto T, Miyazaki T. 
(Paste this link together on one line)
< 
http://titania.annallergy.org/vl=546032/cl=11/nw=1/rpsv/cw/acaai/10811206/v
93n1/s15/p98 >

Curr Opin Allergy Clin Immunol. 2003 Jun;3(3):205-9. 
Update on wheat hypersensitivity.
Palosuo K.
(Paste this link together on one line)
< http://www.co-allergy.com/pt/re/coallergy/abstract.00130832-200306000-
00009.htm >

J Allergy Clin Immunol. 2001 Oct;108(4):634-8.
Wheat omega-5 gliadin is a major allergen in children with immediate 
allergy to ingested wheat.
Palosuo K, Varjonen E, Kekki OM, Klemola T, Kalkkinen N, Alenius H, 
Reunala T. 
< http://dx.doi.org/10.1067/mai.2001.118602 >

Allergy. 1999 Aug;54(8):851-6. 
Wheat allergy: diagnostic accuracy of skin prick and patch tests and 
specific IgE.
Majamaa H, Moisio P, Holm K, Turjanmaa K. 
< http://dx.doi.org/10.1034/j.1398-9995.1999.00081.x  >

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