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A guest post from Kalle Reichelt, MD, PhD (in reply to the recent posts on
this topic).
 
From: K.L.Reichelt @ rh.uio.no (Kalle Reichelt)
Date: 09/11/95 09:03:45 AM
Subject: Downs syndrome and gut permeability
 
Hi.
Many Downs syndrome children have very high levels of IgA and also IgG
antibodies to food proteins (1,2) even if most of these do not have
endomycium antiboides and a normal gut lining. We have interpreted this as
indicating increased gut permeability but in most cases not a coeliac
condition. There is an inverse relationship between the size of the
children and the level of these antibodies(1). Apparently also Downs
syndrome with autism is more frequent than expected (3) . I have four
children with this combined state so far.
It also is very relevant that Shattock found peptide increases in  the
urine of such patients (4).
We also find substantial peptide increases in coeliacs( Reichelt et al
submitted) and thus confirming data published on increases in hydrolysis
released amino acids in the urine of coeliacs. (5)
Ref:
1:Kanavin \ et al (1988) Immunological studies of patients with Downs
syndrome.Acta Med Scand 224: 474-477.
2: Reichelt KL et al (1994)Increased levels of antibodies to food proteins
in Down syndrome. Acta paediat Japon. 36: 489-492.
3:Howlin P et al (1995)The recognition of autism in children with Down
syndrome -implications for intervention and some speculations about
pathology. develop Med and Child neurol . 37: 398-414.
4:Shattock P et al (1990) Role of neuropeptides in autism and their
relationships with classical neurotransmitters .Brain Dysfunct 3: 328-346.
5:Klosse JA et al (1971)An automated chromatographic system for the
combined analysis of urinary peptides and amino acids .Clin Chim Acta 42:
409-422.
 
All the best                            Cheers
 
                                                TINY
 
K. Reichelt
Pediatric Research Institute
N-0027 Oslo, Norway
Tel: +47 22 86 90 45
Fax: +47 22 86 91 17
E-mail: [log in to unmask]