Please add this to the research on APOE-4 via my friend:
"Diane,
I scouted around for something more readable than what I sent you before. Well, here is a reference which is summarized and easier to understand. Here is how you get there: google "paleohacks apoe-4"; then click on "ApoE-4-The Ancestral Allele" which will take you to a summary of: Apolipoprotein E (APOE) allele distribution in the world. Is APOE 4 a 'thrify' allele? by RM Corbo & R. Scacchi.
Good luck. I stand by what I said: human genes love to gamble, and will respond quickly to challenges from the environment.
Our environment is not the same as it was a few thousand years ago."
Thanks.
-dh