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I am reposting for Becky Ilog [log in to unmask]

A medical journal article published today in Alimentary Pharmacology &
Therapeutics caught my eye: 

Clinical trial: B vitamins improve health in patients with coeliac
disease living on a gluten-free diet C. HALLERT, M. SVENSSON, J.
I am reposting for Becky Ilog [log in to unmask]

THOLSTRUP, B. HULTBERG Abstract Published Online: 20 Jan 2009 DOI
10.1111/j.1365-2036.2009.03945.x 

Here is the abstract: ABSTRACT Background Patients with coeliac disease
living on a gluten-free diet show vitamin deficiency and reduced
subjective health status. 

Aim To study the biochemical and clinical effects of B vitamin
supplementation in adults with longstanding coeliac disease. 

Methods In a double blind placebo controlled multicentre trial, 65
coeliac patients (61% women) aged 45-64 years on a strict gluten-free
diet for several years were randomized to a daily dose of 0.8 mg folic
acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months.
The outcome measures were psychological general well-being (PGWB) and
the plasma total homocysteine (tHcy) level, marker of B vitamin status. 

Results Fifty-seven patients (88%) completed the trial. The tHcy level
was baseline median 11.7 micromoles/L (7.4 - 23.0), significantly higher
than in matched population controls [10.2 micromoles/L (6.7 - 22.6) (P <
0.01)]. Following vitamin supplementation, tHcy dropped a median of 34%
(P < 0.001), accompanied by significant improvement in well-being (P <
0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for
patients with poor well-being. 

Conclusions Adults with longstanding coeliac disease taking extra B
vitamins for 6 months showed normalized tHcy and significant improvement
in general well-being, suggesting that B vitamins should be considered
in people advised to follow a gluten-free diet. NOTE: The information
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Mike Jones <[log in to unmask]> Orlando, FL, USA
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