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--- On Thu, 2/26/09, Meir Weiss <[log in to unmask]> wrote:
> From: Meir Weiss <[log in to unmask]>
> Subject: Coffee Intake Associated With Decreased Stroke Risk in Women
> To: [log in to unmask]
> Date: Thursday, February 26, 2009, 10:32 AM
> http://www.medscape.com/viewarticle/588403?src=mp&spon=17&uac=119129SZ
>
> Coffee Intake Associated With Decreased Stroke Risk in
> Women
>
>
> Susan Jeffrey
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> To earn CME related to this news article, click here.
>
> February 18, 2009 - A new analysis of data from the
> Nurses' Health Study
> shows that long-term consumption of up to 4 or more cups of
> coffee per day
> was not associated with an increased risk for stroke and
> actually appeared
> to be protective against stroke in women who did not also
> smoke.
>
> Among women who currently smoked, there appeared to be no
> effect of coffee
> intake, neither raising nor lowering stroke risk. No
> association was seen
> with other caffeinated drinks, including tea or soft
> drinks, and
> decaffeinated coffee still showed a trend toward a
> protective effect.
>
> "Our data support the hypothesis that components in
> coffee other than
> caffeine may lower the risk for stroke, although the
> association was modest
> and the biological mechanism is unclear," the
> researchers, with first author
> Ester Lopez-Garcia, PhD, from the Universidad Autonoma de
> Madrid, Spain, and
> colleagues at the Harvard School of Public Health, in
> Boston, Massachusetts,
> conclude.
>
> Their report was published online February 16 and will
> appear in the March 3
> print issue of Circulation.
>
> Studies Inconclusive
>
> Recently reported data have suggested that coffee does not
> increase the risk
> for coronary heart disease and may be protective against
> type 2 diabetes,
> the authors write. Data on the relationship of coffee
> intake and stroke are
> "sparse," they note, and have been somewhat
> contradictory.
>
> In this study, they analyzed data from the Nurses'
> Health Study, a
> prospective cohort of 83,076 women who were free of stroke,
> coronary heart
> disease, diabetes, or cancer at baseline. Coffee
> consumption was assessed
> first in 1980 and then every 2 to 4 years thereafter, with
> follow-up over 24
> years through 2004.
>
> Over this period, 2280 strokes occurred among the women:
> 1224 ischemic
> strokes, 426 hemorrhagic strokes, and 630 strokes of
> undetermined cause.
>
> After adjustment for factors including age, smoking status,
> body-mass index,
> physical activity, alcohol intake, menopausal status,
> hormone therapy,
> aspirin use, and dietary factors, they found no increase in
> the risk for
> stroke associated with increasing coffee intake, and
> evidence for a
> protective effect for intakes of 2 or more cups per day vs
> less than 1 cup
> per month (P for trend = .003)
>
> Relative Risk of Stroke With Increasing Coffee Intake
> Coffee Intake (Cups)
> Relative Risk 95% CI
> < 1/month 1.0 (Referent) -
> 1/month - 4/week 0.98 0.84 - 1.15
> 5 - 7/week 0.88 0.77 - 1.02
> 2 - 3/day 0.81 0.70 - 0.95
> > 4/day 0.80 0.64 - 0.98
>
>
>
> After further adjustment for high blood pressure,
> hypercholesterolemia, and
> type 2 diabetes, the inverse association remained
> significant, the authors
> noted.
>
> Because cigarette smoking is more common in coffee drinkers
> and a strong
> confounder of stroke risk, they stratified the data by
> smoking status. They
> found that the association was stronger among never or past
> smokers than
> among current smokers, suggesting that "the potential
> benefit of coffee
> consumption cannot counterbalance the detrimental effects
> smoking has on
> health," the authors write.
>
> Relative Risk of Stroke With Increasing Coffee Consumption
> by Smoking Status
> Smoking Status Relative Risk (> 4 Cups/Day vs < 1
> Cup/Month) 95% CI
> Never or past smokers 0.57 0.39 - 0.84
> Current smokers 0.97 0.63 - 1.48
>
>
>
> Other drinks containing caffeine, including tea and
> caffeinated soft drinks,
> were not associated with stroke, they note. Decaffeinated
> coffee was
> associated with a trend toward lower stroke risk after
> adjustment for
> consumption of caffeinated coffee (relative risk, 0.89 for
> 2 or more cups
> per day vs less than 1 per month; 95% CI, 0.73 - 1.08; P
> for trend = .05).
>
> More research will be required before implications for
> public health and
> clinical practice are considered, the authors write.
> However, there does not
> at least appear to be any risk for stroke associated with
> coffee intake for
> those who already drink it.
>
> In a news release from the American Heart Association, Dr.
> Lopez-Garcia
> noted, "Anyone with health problems that can be
> worsened by coffee
> (insomnia, anxiety, hypertension, or heart problems) should
> talk to their
> doctor about their specific risk."
>
> The study was funded by grants from the National Institutes
> of Health. The
> authors have disclosed no relevant financial relationships.
>
> Circulation. Published online February 16, 2009. Abstract
>
>
>
>
> Related Links
> News
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> Cardiovascular
> Deaths
>
>
> Resource Centers
> Integrative Medicine Resource Center
> Nutrition
> Stroke/Cerebrovascular Disease
>
>
>
> ----------------------------------------------------------------------------
> ----
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>
> ----------------------------------------------------------------------------
> ----
>
>
>
> Susan Jeffrey is News Editor for Medscape Neurology &
> Neurosurgery. She has
> been writing principally for physician audiences for nearly
> 20 years. Most
> recently, she was news editor of thekidney.org and also
> wrote for
> theheart.org; both of these Web sites have been acquired by
> WebMD. Prior to
> that, she spent 10 years covering neurology topics for a
> Canadian newspaper
> for physicians. She can be contacted at
> [log in to unmask]
>
>
> Medscape Medical News 2009. C 2009 Medscape
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