From: [log in to unmask] [mailto:[log in to unmask]] On Behalf Of Ginger
Campbell, MD
Sent: September 19, 2011 15:38
To: Meir Weiss
Subject: Brain Science Podcast 77: Neurobiology of Placebos with Fabrizio
Benedetti
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for this month's podcast. Please send me your feedback and suggestions for
how I can improve this newsletter.
Ginger Campbell, MD
Dr. Fabrizio Benedetti is one of the world's leading researchers of the
neurobiology of placebos. In a recent interview (BSP 77) he explained to me
that he believes that "today we are in a very good position to describe,
from a biological and from an evolutionary approach, the doctor-patient
relationship, and the placebo effect, itself."
To appreciate Dr. Benedetti's work one must first realize that his approach
differs from that of the typical clinical trial. As he observed, "To the
clinical trialist, a placebo effect means any improvement which may take
place after placebo administration. To the neurobiologist, a placebo
response, or placebo effect means only something active in the brain
happening after placebo administration: learning, anxiety reduction,
activation of reward mechanisms."
In contrast, he explains "The real placebo response, the real placebo effect
is a psychobiological phenomenon. It is something active happening in the
brain after placebo administration: like learning, like anxiety reduction,
and such like." Brain Science Podcast 77 provides an introduction to this
complex, but fascinating topic.
Listen to Episode 77
Episode Transcript (Free PDF)
References
• Benedetti F, Mayberg HS, Wager TD, Stohler CS, Jon-Kar Zubieta J (2005)
Neurobiological Mechanisms of the Placebo Effect. The Journal of
Neuroscience, 25,10390-10402. (Full article)
• Benedetti F (2009) Placebo Effects: Understanding the mechanisms in health
and disease. Oxford University Press.
• Benedetti F (2011) The Patient's Brain: The neuroscience behind the
doctor-patient relationship. Oxford University Press.
• Levine JD, Gordon NC and Fields, HL (1978) The mechanisms of placebo
analgesia. Lancet, 2, 654-7. (Abstract)
• Levine JD, Gordon NC and Fields, HL (1978) "The mechanisms of placebo
analgesia." Lancet, 2, 654-7. (Abstract). See also a follow-up paper: Levine
JD, Gordon NC, Bornstein JC, and H L Fields HL (1979) "Role of pain in
placebo analgesia." Proc Natl Acad Sci 76(7): 3528-3531. (full text)
• Volkow, ND, Wang JG, Ma Y, Fowler JS, Zhu W, Maynard L et al. (2003)
Expectation enhances the regional brain metabolic and the reinforcing
effects of stimulants in cocaine abusers. Journal of Neuroscience, 23,
11261-8. (Full text)
• de la Fuente-Fernández R, et al. (2001) Expectation and Dopamine Release:
Mechanism of the Placebo Effect in Parkinson's Disease. Science 293, 1164.
(Abstract)
• Benedetti F, Colloca L, Torre E et al. (2004) Placebo-responsive Parkinson
patients show decreased activity in single neurons of the subthalamic
nucleus. Nature Neuroscience, 7, 587-88. (Abstract)
• Herrnstein RJ, (1962) Placebo Effect in the Rat. Science 138, 677-678.
• Linde K, Witt CM, Streng A et al. (2007) The impact of patient expectation
in four randomized control trials of acupuncture in patients with chronic
pain. Pain, 128, 264-71. (Abstract)
• See Episode Transcript for additional references.
Announcements
• The Brain Science Podcast is made possible by Listener Support. Don't
forget to tell your friends or leave a review in iTunes.
• Please check out my Books and Ideas podcast. Later this month I will be
posting an interview with Carol Tavris, co-author (with Elliot Aronson) of
Mistakes Were Made (But Not by Me): Why We Justify Foolish Beliefs, Bad
Decisions, and Hurtful Acts.
• Don't forget to leave your comments in the BSP Guest Book.
Corrections
• 32:48 only NON-members are eligible to get a free audiobook download from
our sponsor at http://audiblepodcast.com/brainscience.
• Dr. Benedetti's first book is called Placebo Effects, not Placebo
"responses".
• Special Thanks to Lori Wolfson for finding this mistakes and correcting
them in the episode transcript.
Listen to Episode 77
Episode Transcript (Free PDF)
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